About: The effect of psilocin on memory and locomotion on Wistar rats

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	- (cs) Administration of the serotonin (5-HT)2A/1A receptor agonist psilocin (4-hydroxy-N,N-dimethyltryptamine) causes specific behavioural changes including deficit in cognitive functions and hallucinations in humans and psychotic-like behaviour in animals. The first objective of the present study was to compare the effect of different doses of psilocin on pre-pulse inhibition of the startle response (PPI) and locomotor activity in an open-field test. The second objective was to examine the effect of psilocin on working and reference memory in the Morris water maze (MWM). Male Wistar rats were divided into three groups, a control goup and two experimental groups. Experimental groups received two different doses (1 mg/kg and 4 mg/kg) of psilocin and control group received an adequate volume of saline. Results demonstrated that the lower dose of psilocin disrupted sensorimotor gating in PPI paradigm. Both doses decreased locomotor activity in the open-field. Psilocin also impaired spatial efficiency in MWM, a Administration of the serotonin (5-HT)2A/1A receptor agonist psilocin (4-hydroxy-N,N-dimethyltryptamine) causes specific behavioural changes including deficit in cognitive functions and hallucinations in humans and psychotic-like behaviour in animals. The first objective of the present study was to compare the effect of different doses of psilocin on pre-pulse inhibition of the startle response (PPI) and locomotor activity in an open-field test. The second objective was to examine the effect of psilocin on working and reference memory in the Morris water maze (MWM). Male Wistar rats were divided into three groups, a control goup and two experimental groups. Experimental groups received two different doses (1 mg/kg and 4 mg/kg) of psilocin and control group received an adequate volume of saline. Results demonstrated that the lower dose of psilocin disrupted sensorimotor gating in PPI paradigm. Both doses decreased locomotor activity in the open-field. Psilocin also impaired spatial efficiency in MWM, a (en)
Title	The effect of psilocin on memory and locomotion on Wistar rats Účinek psilocinu na pamět a lokomoci u potkanů kmene Wistar (cs) The effect of psilocin on memory and locomotion on Wistar rats (en)
skos:prefLabel	The effect of psilocin on memory and locomotion on Wistar rats Účinek psilocinu na pamět a lokomoci u potkanů kmene Wistar (cs) The effect of psilocin on memory and locomotion on Wistar rats (en)
skos:notation	RIV/00023752:_____/07:00000804!RIV08-MZ0-00023752
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1M0517), P(GA309/07/0341), P(NR9178)
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Páleníček, Tomáš Bubeníková-Valešová, Věra
http://linked.open.../riv/druhVysledku	W - Uspořádání (zorganizování) workshopu
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	419069
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/07:00000804
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	psilocin; cognitive functions; Morris water maze; rat (en)
http://linked.open.../riv/klicoveSlovo	Morris water maze psilocin cognitive functions rat
http://linked.open...ontrolniKodProRIV	[EC66DBDC83E2]
http://linked.open...v/mistoKonaniAkce	Brno
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	37 (xsd:int)
http://linked.open...nichUcastnikuAkce	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application) Influence of metabotropic glutamate receptor agonists on cognitive deficit in animal model of schizophrenia like behavioral. Behavioral pharmacology of spatial cognition and its application in research of an snímal model of schizophrenia
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/statKonaniAkce	CZ - Česká republika
http://linked.open...iv/tvurceVysledku	Páleníček, Tomáš Bubeníková-Valešová, Věra Rambousek, L. Valeš, K. Stuchlík, A.
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/ukonceniAkce	2007-04-29 (xsd:date)
http://linked.open.../riv/zahajeniAkce	2007-04-26 (xsd:date)

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