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| Description
| - AIM: Previous studies have suggested altered structural and functional asymmetry of the brain in schizophrenia. METHODS: Functional MRI was used to assess differences in cortical activation during a verbal task in Broca's area and its contralateral homologue in four pairs of right-handed monozygotic (MZ) twins discordant and concordant for schizophrenia with low and high familial loading for the illness and four healthy control MZ twin pairs. RESULTS: Pooled data from all subjects with schizophrenia showed increased activation in the right homologue of Broca's area in contrast to healthy individuals. Concordant twins (i.e. high familial loading group) showed prominent between co-twin differences in lateralization index within given region of interest. Intra-pair differences in lateralization index were significantly higher in concordant twins compared to the controls (0.69+/-0.4 vs. 0.13+/-0.13, P<0.03), albeit no significant differences in the variable were shown between the discordant a
- AIM: Previous studies have suggested altered structural and functional asymmetry of the brain in schizophrenia. METHODS: Functional MRI was used to assess differences in cortical activation during a verbal task in Broca's area and its contralateral homologue in four pairs of right-handed monozygotic (MZ) twins discordant and concordant for schizophrenia with low and high familial loading for the illness and four healthy control MZ twin pairs. RESULTS: Pooled data from all subjects with schizophrenia showed increased activation in the right homologue of Broca's area in contrast to healthy individuals. Concordant twins (i.e. high familial loading group) showed prominent between co-twin differences in lateralization index within given region of interest. Intra-pair differences in lateralization index were significantly higher in concordant twins compared to the controls (0.69+/-0.4 vs. 0.13+/-0.13, P<0.03), albeit no significant differences in the variable were shown between the discordant a (en)
- Dosavadní výzkum poukázal na odchylky v strukturální a funkční asymetrii mozku u schizofrenie. Metodika: Funkční magnetická rezonance byla použita k posouzení rozdílu v kortikální aktivaci během testu slovní plynulosti v Brocově oblasti a jeho kontralaterálním homologu u čtyř párů pravorukých jednovaječných dvojčat konkordantních a diskordantních pro schizofrenii s vysokou a nízkou rodinnou zátěží schizofrenním onemocněním a čtyř párů zdravých monozygotních dvojčat. Výsledky: sdružená data od všech subjektů se schizofrenií ukázala u nemocných v porovnání se zdravými kontrolami zvýšenou aktivaci v homoglní oblasti Brocově centru v pravé hemisféře. Konkordantní dvojčata (tedy skupina se zvýšenou rodinnou zátěží schizofrenním onemocněním) vykazovala v dané oblasti zájmu nápadné vnitropárové rozdíly v lateralizačním indexu. Vnitropárové rozdíly v lateralizačním indexu byly signifikantně vyšší u konkordantních dvojčat v porovnání s kontrolami (0.69+/-0.4 vs. 0.13+/-0.13, P<0.03), ačkoliv mezi diskordan (cs)
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| Title
| - Language lateralization in monozygotic twins discordant and concordant for schizophrenia. A fMRI pilot study
- Lateralizace řečových funkcí u jednovaječných dvojčat konkordantních a diskordantních pro schizofrenii (cs)
- Language lateralization in monozygotic twins discordant and concordant for schizophrenia. A fMRI pilot study (en)
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| skos:prefLabel
| - Language lateralization in monozygotic twins discordant and concordant for schizophrenia. A fMRI pilot study
- Lateralizace řečových funkcí u jednovaječných dvojčat konkordantních a diskordantních pro schizofrenii (cs)
- Language lateralization in monozygotic twins discordant and concordant for schizophrenia. A fMRI pilot study (en)
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| skos:notation
| - RIV/00023752:_____/07:00000534!RIV08-MZ0-00023752
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00023752:_____/07:00000534
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - fMRI; schizophrenia; language lateralization; monozygotic twins (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - FR - Francouzská republika
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Horáček, Jiří
- Hájek, Tomáš
- Höschl, Cyril
- Kožený, Jiří
- Tintěra, J.
- Hájek, M.
- Španiel, Filip
- Dezortová, M.
- Dockery, Colleen Anne
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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