About: Viral infection, glutamatergic deficit and behavioral changes in animal model of schizophrenia

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About: Viral infection, glutamatergic deficit and behavioral changes in animal model of schizophrenia Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Retroviruses can disrupt brain development, cause neuronal death and induce behavioural changes and therefore they have been proposed to play a role in the etiology of schizophrenia. Quinolinic acid (QUIN), released from retrovirus-infected brain macrophages and microglia, might be responsible, at least in part, for most of the proposed alterations. Intracerebroventricular infusion of QUIN to rat pups did cause a neuronal damage and evoked a subsequent diminution of the specific membrane binding of glutamate and changed their exploratory and acoustic startle activities in early adulthood. The changes were modified (potentiated) by increased levels of brain dopamine and inhibited by haloperidol and clozapine. Our present data suggest that increased levels of QUIN in neonatal rat brain can induce changes in the brain development and function have effects that exhibit some similarities to human schizophrenia. Retroviruses can disrupt brain development, cause neuronal death and induce behavioural changes and therefore they have been proposed to play a role in the etiology of schizophrenia. Quinolinic acid (QUIN), released from retrovirus-infected brain macrophages and microglia, might be responsible, at least in part, for most of the proposed alterations. Intracerebroventricular infusion of QUIN to rat pups did cause a neuronal damage and evoked a subsequent diminution of the specific membrane binding of glutamate and changed their exploratory and acoustic startle activities in early adulthood. The changes were modified (potentiated) by increased levels of brain dopamine and inhibited by haloperidol and clozapine. Our present data suggest that increased levels of QUIN in neonatal rat brain can induce changes in the brain development and function have effects that exhibit some similarities to human schizophrenia. (en)
Title	Viral infection, glutamatergic deficit and behavioral changes in animal model of schizophrenia Viral infection, glutamatergic deficit and behavioral changes in animal model of schizophrenia (en)
skos:prefLabel	Viral infection, glutamatergic deficit and behavioral changes in animal model of schizophrenia Viral infection, glutamatergic deficit and behavioral changes in animal model of schizophrenia (en)
skos:notation	RIV/00023752:_____/03:00000323!RIV/2004/MZ0/L28004/N
http://linked.open.../vavai/riv/strany	128-130
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NF6031), P(NF7626)
http://linked.open...iv/cisloPeriodika	Suppl. 2
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Šťastný, František Höschl, Cyril Tejkalová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	633033
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/03:00000323
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	schizophrenia; animal model; quinolinic acid; NMDA receptor; dopamine; haloperidol; clozapine; acoustic startle reaction; prepulse inhibition; open field test (en)
http://linked.open.../riv/klicoveSlovo	NMDA receptor open field test animal model clozapine schizophrenia quinolinic acid dopamine haloperidol prepulse inhibition acoustic startle reaction
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[72944537B4D7]
http://linked.open...i/riv/nazevZdroje	Psychiatrie
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Levels of brain glutamate and subunit composition of glutamate receptor of NMDA type in schiziphrenia: experimantal and clinical study. Role of glutamatergic system in neurodevelopmental animal model of schizophrenia.
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Höschl, Cyril Šťastný, František Tejkalová, Hana Balcar, Vladimír Joseph
issn	1211-7579
number of pages	3 (xsd:int)

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