About: Language lateralization in monozygotic twins discordant for schizophrenia. Evidence from functional MRI

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About: Language lateralization in monozygotic twins discordant for schizophrenia. Evidence from functional MRI Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Anatomical and functional studies have shown reduced cerebral asymmetry and functional lateralization in schizophrenia. The aim of this study was to assess the relative contribution of nongenetic factors in previously reported decreased language lateralization in schizophrenia using a co-twin control study. The authors examined the hemispheric dominance for language processing by means of functional MRI in four monozygotic twin pairs discordant for schizophrenia. Subjects were scanned while engaged in verbal fluency task. All twins were right-handed. The results indicate that language processing is less lateralized in affected twins compared with their well co-twins (a mean laterality index of 0,73 versus 0,90 respectively, difference p < 0,05). Differences in language lateralization between affected and well co-twins could suggest nongenetic neurodevelopmental reorganization within the network mediating language in twins with schizophrenia. Anatomical and functional studies have shown reduced cerebral asymmetry and functional lateralization in schizophrenia. The aim of this study was to assess the relative contribution of nongenetic factors in previously reported decreased language lateralization in schizophrenia using a co-twin control study. The authors examined the hemispheric dominance for language processing by means of functional MRI in four monozygotic twin pairs discordant for schizophrenia. Subjects were scanned while engaged in verbal fluency task. All twins were right-handed. The results indicate that language processing is less lateralized in affected twins compared with their well co-twins (a mean laterality index of 0,73 versus 0,90 respectively, difference p < 0,05). Differences in language lateralization between affected and well co-twins could suggest nongenetic neurodevelopmental reorganization within the network mediating language in twins with schizophrenia. (en)
Title	Language lateralization in monozygotic twins discordant for schizophrenia. Evidence from functional MRI Language lateralization in monozygotic twins discordant for schizophrenia. Evidence from functional MRI (en)
skos:prefLabel	Language lateralization in monozygotic twins discordant for schizophrenia. Evidence from functional MRI Language lateralization in monozygotic twins discordant for schizophrenia. Evidence from functional MRI (en)
skos:notation	RIV/00023752:_____/03:00000321!RIV/2004/MZ0/L28004/N
http://linked.open.../vavai/riv/strany	301-303
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NF6794)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Horáček, Jiří Kožený, Jiří Hájek, Tomáš Španiel, Filip
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	613167
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/03:00000321
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	monozygotic twins discordant for schizophrenia; fMRI; language lateralization (en)
http://linked.open.../riv/klicoveSlovo	fMRI language lateralization monozygotic twins discordant for schizophrenia
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[8273ABF20CA8]
http://linked.open...i/riv/nazevZdroje	Psychiatrie
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Hippocampal impairment in schizophrenia: proton magnetic resonance spectroscopy study and dermatoglyphic analysis
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Horáček, Jiří Hájek, Tomáš Kožený, Jiří Hájek, Milan Španiel, Filip Dezortová, Monika Tintěra, Jaroslav Dockery, Colleen Harantová, Pavlína
issn	1211-7579
number of pages	3 (xsd:int)

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