About: Calcium dyshomeostasis in the course of disease in individual patients with Alzheimer´s dementia

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About: Calcium dyshomeostasis in the course of disease in individual patients with Alzheimer´s dementia Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Destabilization of intracellular calcium homeostasis in neurons has been implicated in the pathogenesis of Alzheimer´s dementia (AD). In this study the disturbed calcium homeostasis was examined in platelets of AD patients during the course of the disease and on individual basis. There were no significant differences in calcium homeostasis between mild, moderate and severe stages of AD (n=46), but significant changes were found in all AD stages compared to age-matched nondemented control subjects (n=18). In individual, long term monitored AD patients, the percentage of increase in platelet free intracellular calcium level, in the presence of 1mM calcium in the incubation medium above the basal value, decreased with the progression of the disease in allcases (n=6). Destabilization of intracellular calcium homeostasis in neurons has been implicated in the pathogenesis of Alzheimer´s dementia (AD). In this study the disturbed calcium homeostasis was examined in platelets of AD patients during the course of the disease and on individual basis. There were no significant differences in calcium homeostasis between mild, moderate and severe stages of AD (n=46), but significant changes were found in all AD stages compared to age-matched nondemented control subjects (n=18). In individual, long term monitored AD patients, the percentage of increase in platelet free intracellular calcium level, in the presence of 1mM calcium in the incubation medium above the basal value, decreased with the progression of the disease in allcases (n=6). (en)
Title	Calcium dyshomeostasis in the course of disease in individual patients with Alzheimer´s dementia Calcium dyshomeostasis in the course of disease in individual patients with Alzheimer´s dementia (en)
skos:prefLabel	Calcium dyshomeostasis in the course of disease in individual patients with Alzheimer´s dementia Calcium dyshomeostasis in the course of disease in individual patients with Alzheimer´s dementia (en)
skos:notation	RIV/00023752:_____/03:00000318!RIV/2004/MZ0/L28004/N
http://linked.open.../vavai/riv/strany	53-56
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ00000023752)
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Němcová, Veronika Řípová, Daniela
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	600258
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/03:00000318
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Alzheimer´s dementia; dyshomeostasis of calcium; platelets; the course of disease (en)
http://linked.open.../riv/klicoveSlovo	platelets Alzheimer´s dementia dyshomeostasis of calcium the course of disease
http://linked.open...ontrolniKodProRIV	[55EDEA92F3EE]
http://linked.open...i/riv/mistoVydani	Bologna
http://linked.open...vEdiceCisloSvazku	Neuveden
http://linked.open...i/riv/nazevZdroje	New Trends in Alzheimer and Parkinson Related Disorders
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2003
http://linked.open...iv/tvurceVysledku	Jirák, Roman Řípová, Daniela Platilová, Veronika
http://linked.open...n/vavai/riv/zamer	Zjišťování příčin psychiatrické morbidity a zvýšení účinnosti preventivních a terapeutických postupů v péči o duševní zdraví obyvatel České republiky
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Monduzzi Editore
https://schema.org/isbn	88-7587-023-3

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