About: Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801

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About: Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Haloperidol is a potent D2 antagonist, belonging to the so-called group of typical antipsychotics. It is effectively used in the treatment of schizophrenia. In our experimental setting we have evaluated the effects of haloperidol on psychosis-like reaction induced by non-competitive NMDA glutamate receptor antagonist, MK-801. We have monitored the locomotor reaction of rats in the open field, whereas we have targeted to evaluate the effects of haloperidol on hyperlocomotion induced by MK-801. We have found that MK-801 induced hyperolocomotor reaction was efficiently diminished by administration of haloperidol in a dose dependent manner. In our experimental setting we conclude that haloperidol was effective in counteracting MK-801 induced hyperlocomotion. Inasmuch as this model serves as a model of psychosis, we can extrapolate that haloperidol has an antipsychotic effect. Haloperidol is a potent D2 antagonist, belonging to the so-called group of typical antipsychotics. It is effectively used in the treatment of schizophrenia. In our experimental setting we have evaluated the effects of haloperidol on psychosis-like reaction induced by non-competitive NMDA glutamate receptor antagonist, MK-801. We have monitored the locomotor reaction of rats in the open field, whereas we have targeted to evaluate the effects of haloperidol on hyperlocomotion induced by MK-801. We have found that MK-801 induced hyperolocomotor reaction was efficiently diminished by administration of haloperidol in a dose dependent manner. In our experimental setting we conclude that haloperidol was effective in counteracting MK-801 induced hyperlocomotion. Inasmuch as this model serves as a model of psychosis, we can extrapolate that haloperidol has an antipsychotic effect. (en)
Title	Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801 Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801 (en)
skos:prefLabel	Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801 Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801 (en)
skos:notation	RIV/00023752:_____/03:00000282!RIV/2004/MSM/L28004/N
http://linked.open.../vavai/riv/strany	50-54
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(LN00B122), P(NF6033), P(NL7684)
http://linked.open...iv/cisloPeriodika	Suppl. 3
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Horáček, Jiří Páleníček, Tomáš Bubeníková-Valešová, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	605298
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/03:00000282
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	haloperidol; MK-801; schizophrenia; animal model; locomotion; antipsychotics; dopamine (en)
http://linked.open.../riv/klicoveSlovo	MK-801 locomotion animal model schizophrenia antipsychotics dopamine haloperidol
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[F0FB7BCB00AE]
http://linked.open...i/riv/nazevZdroje	Psychiatrie
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Neuropsychiatric Research Center The deficit of cognitive function in scizophrenia and central serotonergic activity The role of serotonin activity in unique action of atypical antipsychotics in animal model of schizophrenia
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Horáček, Jiří Páleníček, Tomáš Bubeníková, Věra
issn	1211-7579
number of pages	5 (xsd:int)

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