About: Role of glutamate receptor in the brain capillary barrier

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About: Role of glutamate receptor in the brain capillary barrier Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Intracerebroventricular administration of N-acetyl-L-aspartyl-L-glutamate (NAAG) and quinolinic acid (QUIN) significantly increased the permeability of blood brain barrier (BBB) to serum albumin. While NAAG was only effective in the striatum, QUIN also increased the entry of serum albumin into the hippocampus, in addition to the striatum. NMDA receptor antagonist, MK-801 blocked the action of QUIN but not that of NAAG. Neither L-glutamate (L-GLU) nor N-acetyl-L-aspartate (NAA), potential products of thehydrolysis of NAAG, had any effect on the passage of albumin across the BBB. Thus NAAG can change the permeability of the BBB but the changes coincide neither in location nor in pharmacology with the NAAG-induced neurodegeneration in the hippocampus. Intracerebroventricular administration of N-acetyl-L-aspartyl-L-glutamate (NAAG) and quinolinic acid (QUIN) significantly increased the permeability of blood brain barrier (BBB) to serum albumin. While NAAG was only effective in the striatum, QUIN also increased the entry of serum albumin into the hippocampus, in addition to the striatum. NMDA receptor antagonist, MK-801 blocked the action of QUIN but not that of NAAG. Neither L-glutamate (L-GLU) nor N-acetyl-L-aspartate (NAA), potential products of thehydrolysis of NAAG, had any effect on the passage of albumin across the BBB. Thus NAAG can change the permeability of the BBB but the changes coincide neither in location nor in pharmacology with the NAAG-induced neurodegeneration in the hippocampus. (en)
Title	Role of glutamate receptor in the brain capillary barrier Role of glutamate receptor in the brain capillary barrier (en)
skos:prefLabel	Role of glutamate receptor in the brain capillary barrier Role of glutamate receptor in the brain capillary barrier (en)
skos:notation	RIV/00023752:_____/01:00000199!RIV/2002/GA0/L28002/N
http://linked.open.../vavai/riv/strany	134-136
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA309/99/0211)
http://linked.open...iv/cisloPeriodika	Suppl. 2
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Šťastný, František Bubeníková-Valešová, Věra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	694941
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/01:00000199
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	serum albumin leakage, brain capillaries, glutamate, N-acetyl-aspartate, N-acetyl-aspartyl-glutamate, quinolinate (en)
http://linked.open.../riv/klicoveSlovo	glutamate brain capillaries quinolinate serum albumin leakage N-acetyl-aspartate N-acetyl-aspartyl-glutamate
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[381B7AB4731D]
http://linked.open...i/riv/nazevZdroje	Psychiatrie
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Localization, distribution and function of glutamate receptor in brain capillary barrier
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Šťastný, František Bubeníková, Věra Ježová, Daniela Balcar, Vladimír Joseph Pliss, Lioudmila Škultétyová, Ivana
issn	1211-7579
number of pages	3 (xsd:int)

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