About: The effect of helper epitopes and cellular localization of an antigen on the outcome of gene gun DNA immunization     Goto   Sponge   NotDistinct   Permalink

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Description
  • The cellular localization of the antigen produced by DNA vaccines delivered by the gene gun was crucial for the effect of the p30 helper epitope on the E7-specific response, but the stronger immunity against the E7 antigen stimulated with the PADRE epitope was not noticeably dependent on this cellular localization. The higher potency of the PADRE epitope might be caused by its higher affinity to MHC class II molecules resulting in the observed stronger Th1 and weaker Th2 response in comparison with the p30 epitope
  • The cellular localization of the antigen produced by DNA vaccines delivered by the gene gun was crucial for the effect of the p30 helper epitope on the E7-specific response, but the stronger immunity against the E7 antigen stimulated with the PADRE epitope was not noticeably dependent on this cellular localization. The higher potency of the PADRE epitope might be caused by its higher affinity to MHC class II molecules resulting in the observed stronger Th1 and weaker Th2 response in comparison with the p30 epitope (en)
Title
  • The effect of helper epitopes and cellular localization of an antigen on the outcome of gene gun DNA immunization
  • The effect of helper epitopes and cellular localization of an antigen on the outcome of gene gun DNA immunization (en)
skos:prefLabel
  • The effect of helper epitopes and cellular localization of an antigen on the outcome of gene gun DNA immunization
  • The effect of helper epitopes and cellular localization of an antigen on the outcome of gene gun DNA immunization (en)
skos:notation
  • RIV/00023736:_____/14:00010902!RIV15-GA0-00023736
http://linked.open...avai/riv/aktivita
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  • P(GAP501/12/1761), P(NT11541)
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  • 2
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  • 13321
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  • RIV/00023736:_____/14:00010902
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  • helper epitope; DNA vaccine; E7 oncoprotein; gene gun (en)
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  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [2C25841B38C3]
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  • Gene therapy
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  • 21
http://linked.open...iv/tvurceVysledku
  • Šmahel, Michal
  • Ludvíková, Viera
  • Poláková, Ingrid
  • Dušková, Martina
  • Kaštánková, Iva
http://linked.open...ain/vavai/riv/wos
  • 000331217700014
issn
  • 0969-7128
number of pages
http://bibframe.org/vocab/doi
  • 10.1038/gt.2013.81
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