About: Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome

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About: Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.jhoonline.org/content/pdf/1756-8722-6-58.pdf
Description	Myelodysplastic syndromes (MDS) are hematological malignancies of unclear etiology where oxidative stress may contribute to the pathogenesis. Methylarginines, naturally occurring inhibitors of NO synthase, can increase superoxide generation from uncoupled NO synthase. We found significant increase in concentrations of asymmetric dimethylarginine (0.84 0.32 μmol/L, p = 0.0022) and malondialdehyde (0.77 0.11 μmol/L, p < 0.001) in sera of MDS patients vs controls (asymmetric dimethylarginine: 0.56 0.16 μmol/L, malondialdehyde: 0.52 0.07 μmol/L). On the contrary, nitrites concentrations were significantly decreased in MDS patients (1.71 0.46 μmol/L, p = 0.0028) vs controls (2.16 0.38 μmol/L). We suppose that the oxidative stress in MDS is enhanced due to methylated arginines influence on NO synthase activity impairment. Myelodysplastic syndromes (MDS) are hematological malignancies of unclear etiology where oxidative stress may contribute to the pathogenesis. Methylarginines, naturally occurring inhibitors of NO synthase, can increase superoxide generation from uncoupled NO synthase. We found significant increase in concentrations of asymmetric dimethylarginine (0.84 0.32 μmol/L, p = 0.0022) and malondialdehyde (0.77 0.11 μmol/L, p < 0.001) in sera of MDS patients vs controls (asymmetric dimethylarginine: 0.56 0.16 μmol/L, malondialdehyde: 0.52 0.07 μmol/L). On the contrary, nitrites concentrations were significantly decreased in MDS patients (1.71 0.46 μmol/L, p = 0.0028) vs controls (2.16 0.38 μmol/L). We suppose that the oxidative stress in MDS is enhanced due to methylated arginines influence on NO synthase activity impairment. (en)
Title	Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome (en)
skos:prefLabel	Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome (en)
skos:notation	RIV/00023736:_____/13:00010739!RIV14-GA0-00023736
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GBP205/12/G118), P(KAN200670701)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Čermák, Jaroslav Pimková, Kristýna Chrastinová, Leona Dyr, Jan Evangelista Suttnar, Jiří Štikarová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	72928
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/13:00010739
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MDS; chromatography; oxidative stress (en)
http://linked.open.../riv/klicoveSlovo	chromatography oxidative stress MDS
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1FD433B77630]
http://linked.open...i/riv/nazevZdroje	Journal of hematology & oncology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Surface plasmon resonance biosensors and protein arrays for medical diagnostics Nanobiophotonics for future health care
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Dyr, Jan Evangelista Suttnar, Jiří Čermák, Jaroslav Štikarová, Jana Pimková, Kristýna Chrastinová-Mášová, Leona
http://linked.open...ain/vavai/riv/wos	000323675900001
issn	1756-8722
number of pages	2 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/1756-8722-6-58

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