About: A comparative study of deferasirox and deferiprone in the treatment of iron overload in patients with myelodysplastic syndromes

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About: A comparative study of deferasirox and deferiprone in the treatment of iron overload in patients with myelodysplastic syndromes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.leukres.2013.07.021
Description	A comparative study performed in 113 iron overloaded patients with early myelodysplastic syndromes showed a substantial decrease in iron stores ( > 50% of intial values) in 27,7% of patients treated with deferasirox in kontrast to none of the patients treated with deferiprone. Incidence of side effects was similar in both the drugs, however side effects related to deferasirox administration were mostly mild and reversible nad allowed to continue drug admnistration after temporary cesation of the treatment. On the contrary deferiprone administration had to be stopped due to side effects in 20% of patients. Deferasirox represents relatively safe first line chelation treatment in MDS patients. A comparative study performed in 113 iron overloaded patients with early myelodysplastic syndromes showed a substantial decrease in iron stores ( > 50% of intial values) in 27,7% of patients treated with deferasirox in kontrast to none of the patients treated with deferiprone. Incidence of side effects was similar in both the drugs, however side effects related to deferasirox administration were mostly mild and reversible nad allowed to continue drug admnistration after temporary cesation of the treatment. On the contrary deferiprone administration had to be stopped due to side effects in 20% of patients. Deferasirox represents relatively safe first line chelation treatment in MDS patients. (en)
Title	A comparative study of deferasirox and deferiprone in the treatment of iron overload in patients with myelodysplastic syndromes A comparative study of deferasirox and deferiprone in the treatment of iron overload in patients with myelodysplastic syndromes (en)
skos:prefLabel	A comparative study of deferasirox and deferiprone in the treatment of iron overload in patients with myelodysplastic syndromes A comparative study of deferasirox and deferiprone in the treatment of iron overload in patients with myelodysplastic syndromes (en)
skos:notation	RIV/00023736:_____/13:00010730!RIV14-MZ0-00023736
http://linked.open...avai/riv/aktivita	I V
http://linked.open...avai/riv/aktivity	I, V
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Čermák, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	58487
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/13:00010730
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	deferasirox; chelation; Deferiprone; myelodysplasia; side effects; toxicity (en)
http://linked.open.../riv/klicoveSlovo	Deferiprone chelation deferasirox side effects toxicity myelodysplasia
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[4FEECFE02FF6]
http://linked.open...i/riv/nazevZdroje	Leukemia research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	37
http://linked.open...iv/tvurceVysledku	Jonášová, A. Neuwirtová, R. Čermák, Jaroslav Vondráková, J. Bělohlávková, P. Červínek, L.
http://linked.open...ain/vavai/riv/wos	000327539700004
issn	0145-2126
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.leukres.2013.07.021

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