About: Unraveling the complexity of tyrosine kinase inhibitor-resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain

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About: Unraveling the complexity of tyrosine kinase inhibitor-resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1182/blood-2013-03-487728
Description	We found that conventional Sanger sequencing had misclassified or underestimated BCR-ABL mutation status in 55% of the samples, where mutations with 1-15% abundance were detected. A complex clonal texture was uncovered by clonal analysis of samples harbouring multiple mutations and up to thirteen different mutated populations were identified. The landscape of these mutated populations was found to be highly dynamic. The high degree of complexity uncovered by UDS indicates that conventional Sanger sequencing might be an inadequate tool to assess BCR-ABL KD mutation status, that currently represents an important component of the therapeutic decision algorithms. Further evaluation of the clinical usefulness of UDS-based approaches is warranted. We found that conventional Sanger sequencing had misclassified or underestimated BCR-ABL mutation status in 55% of the samples, where mutations with 1-15% abundance were detected. A complex clonal texture was uncovered by clonal analysis of samples harbouring multiple mutations and up to thirteen different mutated populations were identified. The landscape of these mutated populations was found to be highly dynamic. The high degree of complexity uncovered by UDS indicates that conventional Sanger sequencing might be an inadequate tool to assess BCR-ABL KD mutation status, that currently represents an important component of the therapeutic decision algorithms. Further evaluation of the clinical usefulness of UDS-based approaches is warranted. (en)
Title	Unraveling the complexity of tyrosine kinase inhibitor-resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain Unraveling the complexity of tyrosine kinase inhibitor-resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain (en)
skos:prefLabel	Unraveling the complexity of tyrosine kinase inhibitor-resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain Unraveling the complexity of tyrosine kinase inhibitor-resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain (en)
skos:notation	RIV/00023736:_____/13:00010715!RIV14-MZ0-00023736
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT11555)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Broučková, Adéla Klamová, Hana Machová Poláková, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	112703
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/13:00010715
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chronic myeloid leukemia; multiple myeloma; Imatinib; therapy; minority (en)
http://linked.open.../riv/klicoveSlovo	chronic myeloid leukemia multiple myeloma therapy Imatinib minority
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[14FE396B8F45]
http://linked.open...i/riv/nazevZdroje	Blood
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	26 (xsd:int)
http://linked.open...vavai/riv/projekt	DNA fingerprinting in chronic myeloid leukemia
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	122
http://linked.open...iv/tvurceVysledku	Klamová, Hana Broučková, Adéla Machová Poláková, Kateřina Martinelli, G. Haferlach, T. Cavo, M. Russo, D. Baccarani, M. Binotto, G. Bochicchio, M. T. Bresciani, P. Castagnetti, F. Cattina, F. De Benedittis, C. Giannini, B. Gugliotta, G. Horner, D. Iacobucci, I. Iacono, M. Kohlmann, A. Palandri, F. Papayannidis, C. Roller, A. Rosti, G. Soverini, S. Venturi, C.
http://linked.open...ain/vavai/riv/wos	000324056500018
issn	0006-4971
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1182/blood-2013-03-487728

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