About: Current survival measures reliably reflect modern sequential treatment in CML: correlation with prognostic stratifications

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1002/ajh.23508/abstract
Description	The greatest difference between the CCI curves at 5 years after initiating imatinib therapy was observed for the BCR-ABL1 transcripts at 3 months. The 5-year CCI was 94.3% in patients with BCR-ABL1 transcripts10% and 57.1% in patients with BCR-ABL1 transcripts>10% (P=0.005). Therefore, the examination of BCR-ABL1 transcripts at 3 months may help in early identification of patients who are likely to perform poorly with imatinib. On the other hand, CLFS was not significantly affected by the considered stratifications. In conclusion, our results indicate that once the CCgR is achieved, the prognosis is good irrespective of the starting prognostic risks. The greatest difference between the CCI curves at 5 years after initiating imatinib therapy was observed for the BCR-ABL1 transcripts at 3 months. The 5-year CCI was 94.3% in patients with BCR-ABL1 transcripts10% and 57.1% in patients with BCR-ABL1 transcripts>10% (P=0.005). Therefore, the examination of BCR-ABL1 transcripts at 3 months may help in early identification of patients who are likely to perform poorly with imatinib. On the other hand, CLFS was not significantly affected by the considered stratifications. In conclusion, our results indicate that once the CCgR is achieved, the prognosis is good irrespective of the starting prognostic risks. (en)
Title	Current survival measures reliably reflect modern sequential treatment in CML: correlation with prognostic stratifications Current survival measures reliably reflect modern sequential treatment in CML: correlation with prognostic stratifications (en)
skos:prefLabel	Current survival measures reliably reflect modern sequential treatment in CML: correlation with prognostic stratifications Current survival measures reliably reflect modern sequential treatment in CML: correlation with prognostic stratifications (en)
skos:notation	RIV/00023736:_____/13:00010709!RIV14-MZ0-00023736
http://linked.open...avai/riv/aktivita	I N V
http://linked.open...avai/riv/aktivity	I, N, V
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Klamová, Hana Machová Poláková, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	67554
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/13:00010709
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	interferon; cytogenetic response; Imatinib; chronic myeloid leukemia; BCR-ABL; tyrosine kinase inhibitors (en)
http://linked.open.../riv/klicoveSlovo	cytogenetic response tyrosine kinase inhibitors chronic myeloid leukemia BCR-ABL Imatinib interferon
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[86634C81E2B0]
http://linked.open...i/riv/nazevZdroje	American journal of hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	21 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	88
http://linked.open...iv/tvurceVysledku	Dušek, L. Faber, E. Jarošová, M. Klamová, Hana Mayer, J. Ráčil, Z. Tóthová, E. Voglová, J. Machová Poláková, Kateřina Pavlík, T. Mužík, J. Žáčková, D. Cmunt, E. Demitrovičová, L. Indrák, K. Kozák, T. Janoušová, E. Karas, M. Chudej, J. Demečková, E. Markuljak, I.
http://linked.open...ain/vavai/riv/wos	000323313500013
issn	0361-8609
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ajh.23508

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