About: Quantitative monitoring of WT-1 expression in peripheral blood before and after allogenenic stem cell transplantation for acute myeloid leukemia: a useful tool for early detection of minimal residual disease

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About: Quantitative monitoring of WT-1 expression in peripheral blood before and after allogenenic stem cell transplantation for acute myeloid leukemia: a useful tool for early detection of minimal residual disease Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Overexpressed Wilms tumor gene 1 (WT1) has been found in a majority of patients with acute myeloid leukemia (AML). The aim of this study was to confirm the applicability of WT1 expression measurement as a marker of minimal residual disease (MRD). The expression of WT1 gene was measured by real-time polymerase chain reaction in peripheral blood (PB) according to European Leukemia Net (ELN) recommendations. The WT1 expression was related to the expression of a reference gene Abelson (ABL) and the results were calculated as a number of WT1 copies related to 104 copies of ABL gene. The upper normal limit of WT1 expression was set at 50 copies of WT1 to 104 copies of ABL. Morphological, flow cytometry and chimerism examinations were evaluated according to standard protocols. Overexpressed Wilms tumor gene 1 (WT1) has been found in a majority of patients with acute myeloid leukemia (AML). The aim of this study was to confirm the applicability of WT1 expression measurement as a marker of minimal residual disease (MRD). The expression of WT1 gene was measured by real-time polymerase chain reaction in peripheral blood (PB) according to European Leukemia Net (ELN) recommendations. The WT1 expression was related to the expression of a reference gene Abelson (ABL) and the results were calculated as a number of WT1 copies related to 104 copies of ABL gene. The upper normal limit of WT1 expression was set at 50 copies of WT1 to 104 copies of ABL. Morphological, flow cytometry and chimerism examinations were evaluated according to standard protocols. (en)
Title	Quantitative monitoring of WT-1 expression in peripheral blood before and after allogenenic stem cell transplantation for acute myeloid leukemia: a useful tool for early detection of minimal residual disease Quantitative monitoring of WT-1 expression in peripheral blood before and after allogenenic stem cell transplantation for acute myeloid leukemia: a useful tool for early detection of minimal residual disease (en)
skos:prefLabel	Quantitative monitoring of WT-1 expression in peripheral blood before and after allogenenic stem cell transplantation for acute myeloid leukemia: a useful tool for early detection of minimal residual disease Quantitative monitoring of WT-1 expression in peripheral blood before and after allogenenic stem cell transplantation for acute myeloid leukemia: a useful tool for early detection of minimal residual disease (en)
skos:notation	RIV/00023736:_____/13:00010522!RIV14-MZ0-00023736
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NR8748)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Mikulenková, Dana Válková, Veronika Marková, Jana Vítek, Antonín Haškovec, Cedrik Polák, Jaroslav Hájková, Hana Čechová, Hana Marinov, Iuri
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	101217
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/13:00010522
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	WT-1; MRD; allogeneic stem cell transplantation; acute myeloid leukemia (en)
http://linked.open.../riv/klicoveSlovo	acute myeloid leukemia allogeneic stem cell transplantation MRD WT-1
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[1596616362C2]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	New molecular markers of residual disease in acute myeloid leukemia patients and of disease progression in myelodysplastic patients, and prediction of STI-571 responsiveness in chronic myeloid leukemia patients at molecular level.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	60
http://linked.open...iv/tvurceVysledku	Marková, Jana Marinov, Iuri Polák, Jaroslav Čechová, Hana Válková, Veronika Vítek, Antonín Mikulenková, Dana Haškovec, Cedrik Hájková, Hana
http://linked.open...ain/vavai/riv/wos	000320086600011
issn	0028-2685
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.4149/neo_2013_011

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