About: Transcription factors Fli1 and EKLF in the differentiation of megakaryocytic and erythroid progenitor in 5q- syndrome and in Diamond-Blackfan anemia

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About: Transcription factors Fli1 and EKLF in the differentiation of megakaryocytic and erythroid progenitor in 5q- syndrome and in Diamond-Blackfan anemia Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In 5q- syndrome, high Fli1 mRNA levels in the blood and bone marrow mononuclear cells were found. In DBA, Fli1 expression did not differ from the controls. EKLF mRNA level was significantly decreased in the blood and bone marrow of 5q- syndrome and in all DBA patients. We propose that the elevated Fli1 in 5q- syndrome protects megakaryocytic cells from ribosomal stress contrary to erythroid cells and contributes to effective though dysplastic megakaryopoiesis. In 5q- syndrome, high Fli1 mRNA levels in the blood and bone marrow mononuclear cells were found. In DBA, Fli1 expression did not differ from the controls. EKLF mRNA level was significantly decreased in the blood and bone marrow of 5q- syndrome and in all DBA patients. We propose that the elevated Fli1 in 5q- syndrome protects megakaryocytic cells from ribosomal stress contrary to erythroid cells and contributes to effective though dysplastic megakaryopoiesis. (en)
Title	Transcription factors Fli1 and EKLF in the differentiation of megakaryocytic and erythroid progenitor in 5q- syndrome and in Diamond-Blackfan anemia Transcription factors Fli1 and EKLF in the differentiation of megakaryocytic and erythroid progenitor in 5q- syndrome and in Diamond-Blackfan anemia (en)
skos:prefLabel	Transcription factors Fli1 and EKLF in the differentiation of megakaryocytic and erythroid progenitor in 5q- syndrome and in Diamond-Blackfan anemia Transcription factors Fli1 and EKLF in the differentiation of megakaryocytic and erythroid progenitor in 5q- syndrome and in Diamond-Blackfan anemia (en)
skos:notation	RIV/00023736:_____/13:00010001!RIV14-MZ0-00023736
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NT13836)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Vostrý, Martin Čermák, Jaroslav Nováková, Ludmila Beličková, Monika Březinová, Jana Fuchs, Ota Čmejla, Radek Kostečka, Arnošt Šponerová, Dana Holická, Monika Hájková, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	111542
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/13:00010001
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	5q- syndrome; Diamond-Blackfan anemia; EKLF a Fli1; myelodysplastic syndrome; ribosomopathy (en)
http://linked.open.../riv/klicoveSlovo	5q- syndrome EKLF a Fli1 ribosomopathy myelodysplastic syndrome Diamond-Blackfan anemia
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[B60C74FAAF77]
http://linked.open...i/riv/nazevZdroje	Annals of hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	11 (xsd:int)
http://linked.open...cetTvurcuVysledku	19 (xsd:int)
http://linked.open...vavai/riv/projekt	The study of the myelodysplastic syndrome pathogenesis in patients with isolated del(5q) abnormality and the analysis of the effect of lenalidomide
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	92
http://linked.open...iv/tvurceVysledku	Březinová, Jana Holická, Monika Nováková, Ludmila Beličková, Monika Jonášová, A. Neuwirtová, R. Pospíšilová, D. Čermák, Jaroslav Hochová, I. Vondráková, J. Šišková, M. Fuchs, Ota Kostečka, Arnošt Michalová, K. Čmejla, Radek Šponerová, Dana Hájková, Hana Kadlčková, E. Vostrý, Martin
http://linked.open...ain/vavai/riv/wos	000313068700002
issn	0939-5555
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00277-012-1568-1

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