About: The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors

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About: The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.zsf.jcu.cz/jab/10_2/smetana.html
Description	As it is generally known, the heterochromatin is an useful marker of the cell maturity including its pathology. The goal of the study was to provide more information on the heterochromatin DNA state in chromosomes and central gene rich nuclear regions of single proliferating progenitors of human leukemic granulocytes. The computer image densitometry at the single cell level indicated that heterochromatin fibrils of similar width in the central nuclear regions are characterized by a similar DNA heterochromatin condensation state. Thus the DNA segments in heterochromatin fibrils represent masked chromosomal segments, which possibly carry silent genes. This observation is in harmony with the „classical cytology“ according to which such chromatin regions correspond to the chromosomal territories. As it is generally known, the heterochromatin is an useful marker of the cell maturity including its pathology. The goal of the study was to provide more information on the heterochromatin DNA state in chromosomes and central gene rich nuclear regions of single proliferating progenitors of human leukemic granulocytes. The computer image densitometry at the single cell level indicated that heterochromatin fibrils of similar width in the central nuclear regions are characterized by a similar DNA heterochromatin condensation state. Thus the DNA segments in heterochromatin fibrils represent masked chromosomal segments, which possibly carry silent genes. This observation is in harmony with the „classical cytology“ according to which such chromatin regions correspond to the chromosomal territories. (en)
Title	The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors (en)
skos:prefLabel	The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors (en)
skos:notation	RIV/00023736:_____/12:00010472!RIV13-MZ0-00023736
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Klamová, Hana Smetana, Karel Mikulenková, Dana Jirásková, Ilona Hrkal, Zbyněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	131754
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/12:00010472
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	heterochromatin image optical density; chromosomes; central and peripheral nuclear regions; proliferating cells-human leukemic myeloblasts (en)
http://linked.open.../riv/klicoveSlovo	chromosomes heterochromatin image optical density proliferating cells-human leukemic myeloblasts central and peripheral nuclear regions
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[418466E6B1C9]
http://linked.open...i/riv/nazevZdroje	Journal of applied biomedicine
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Hrkal, Zbyněk Klamová, Hana Smetana, Karel Mikulenková, Dana Jirásková, Ilona Zápotocký, M.
http://linked.open...ain/vavai/riv/wos	000300929300005
http://linked.open...n/vavai/riv/zamer	Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	1214-021X
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.2478/v10136-011-0005-4

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