About: The essential transcription factor for granulocyte differentiation, CCAAT/enhancer binding protein alpha (CEBPA), and its mutations or inhibition associated with acute myeloid leukemias

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About: The essential transcription factor for granulocyte differentiation, CCAAT/enhancer binding protein alpha (CEBPA), and its mutations or inhibition associated with acute myeloid leukemias Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	CEBPα induces myeloid differentiation via up-regulation of specific genes involved in granulocyte maturation and in inhibition of myeloid cell proliferation. CEBPA is intronless and generates two isoforms as a result of the differential utilization of alternate translation start codon. CEBPα p30 inhibits DNA binding of CEBPα p42 and its transactivation fiction in the expression of key genes in granulocytic differentiation. CEBPA mutation a methylation of its promoter were detected in acute myeloid leukemia and have prognostic significance. CEBPα induces myeloid differentiation via up-regulation of specific genes involved in granulocyte maturation and in inhibition of myeloid cell proliferation. CEBPA is intronless and generates two isoforms as a result of the differential utilization of alternate translation start codon. CEBPα p30 inhibits DNA binding of CEBPα p42 and its transactivation fiction in the expression of key genes in granulocytic differentiation. CEBPA mutation a methylation of its promoter were detected in acute myeloid leukemia and have prognostic significance. (en)
Title	The essential transcription factor for granulocyte differentiation, CCAAT/enhancer binding protein alpha (CEBPA), and its mutations or inhibition associated with acute myeloid leukemias The essential transcription factor for granulocyte differentiation, CCAAT/enhancer binding protein alpha (CEBPA), and its mutations or inhibition associated with acute myeloid leukemias (en)
skos:prefLabel	The essential transcription factor for granulocyte differentiation, CCAAT/enhancer binding protein alpha (CEBPA), and its mutations or inhibition associated with acute myeloid leukemias The essential transcription factor for granulocyte differentiation, CCAAT/enhancer binding protein alpha (CEBPA), and its mutations or inhibition associated with acute myeloid leukemias (en)
skos:notation	RIV/00023736:_____/12:00010462!RIV13-MZ0-00023736
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06044), Z(MZ0UHKT2005)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Fuchs, Ota
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	134737
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/12:00010462
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	granulocytic differentiation; acute myeloid leukemia; CCAAT/enhancer binding protein alpha (en)
http://linked.open.../riv/klicoveSlovo	acute myeloid leukemia CCAAT/enhancer binding protein alpha granulocytic differentiation
http://linked.open...ontrolniKodProRIV	[05F7EC790B47]
http://linked.open...i/riv/mistoVydani	New York
http://linked.open...i/riv/nazevZdroje	Granulocytes: production, types and roles in disease
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...v/pocetStranKnihy	142 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Experimental Hematology
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Fuchs, Ota
http://linked.open...n/vavai/riv/zamer	Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
number of pages	36 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Nova Science Publishers
https://schema.org/isbn	978-1-61942-806-5

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