About: Immunization with WT1-derived peptides by tattooing inhibits the growth of TRAMP-C2 prostate tumor in mice

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About: Immunization with WT1-derived peptides by tattooing inhibits the growth of TRAMP-C2 prostate tumor in mice Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://journals.lww.com/immunotherapy-journal/Abstract/2012/07000/Immunization_With_WT1_derived_Peptides_by.4.aspx
Description	The expression of the transcription factor encoded by the Wilms tumor gene 1 (WT1) is associated with a variety of human cancers. WT1 protein has been reported to serve as a target antigen for tumor-specific immune responses. We observed that the immunization of mice with peptide vaccines derived from WT1 in a mixture with the CpG adjuvant (ODN 1826) by tattoo administration was superior to subcutaneous delivery of the peptides in combination with CpG formulated with the mineral oil adjuvant or a DNA vaccine or a recombinant vaccinia virus vaccine expressing the truncated WT1 protein. Tattooing with the WT1122–140 and WT1126–134 peptide elicited the response of WT1-specific interferon-γ–producing T cells. Peptide vaccine administered with a tattoo device had an antitumor effect on the growth of the prostate tumor cell line TRAMP-C2, provided that the transforming growth factor-beta produced by tumor cells was neutralized by anti-TGFbeta monoclonal antibody. The expression of the transcription factor encoded by the Wilms tumor gene 1 (WT1) is associated with a variety of human cancers. WT1 protein has been reported to serve as a target antigen for tumor-specific immune responses. We observed that the immunization of mice with peptide vaccines derived from WT1 in a mixture with the CpG adjuvant (ODN 1826) by tattoo administration was superior to subcutaneous delivery of the peptides in combination with CpG formulated with the mineral oil adjuvant or a DNA vaccine or a recombinant vaccinia virus vaccine expressing the truncated WT1 protein. Tattooing with the WT1122–140 and WT1126–134 peptide elicited the response of WT1-specific interferon-γ–producing T cells. Peptide vaccine administered with a tattoo device had an antitumor effect on the growth of the prostate tumor cell line TRAMP-C2, provided that the transforming growth factor-beta produced by tumor cells was neutralized by anti-TGFbeta monoclonal antibody. (en)
Title	Immunization with WT1-derived peptides by tattooing inhibits the growth of TRAMP-C2 prostate tumor in mice Immunization with WT1-derived peptides by tattooing inhibits the growth of TRAMP-C2 prostate tumor in mice (en)
skos:prefLabel	Immunization with WT1-derived peptides by tattooing inhibits the growth of TRAMP-C2 prostate tumor in mice Immunization with WT1-derived peptides by tattooing inhibits the growth of TRAMP-C2 prostate tumor in mice (en)
skos:notation	RIV/00023736:_____/12:00009959!RIV13-MZ0-00023736
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NS10660)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kutinová, Luďa Kryštofová, Jitka Žůrková, Kamila Hainz, Petr Babiarová, Katarina Němečková, Šárka Musil, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	140545
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/12:00009959
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	WT-1; peptide; CpG adjuvant; tattooing; immunization; ELISPOT; IFNgama; TRAMP-C2; prostate tumor; anti-TGFbeta (en)
http://linked.open.../riv/klicoveSlovo	CpG adjuvant ELISPOT IFNgama TRAMP-C2 WT-1 anti-TGFbeta peptide prostate tumor tattooing immunization
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B2307E3C6D05]
http://linked.open...i/riv/nazevZdroje	Journal of immunotherapy
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of experimental vaccine against WT 1 for immunotherapy of tumors
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Musil, Jan Babiarová, Katarina Hainz, Petr Kryštofová, Jitka Kutinová, Luďa Němečková, Šárka Žůrková, Kamila Brabcová, E.
http://linked.open...ain/vavai/riv/wos	000305896000004
issn	1524-9557
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1097/CJI.0b013e3182618381

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