About: Clinical and laboratory features of leukemias at the time of diagnosis: an analysis of 1,004 consecutive patients.

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About: Clinical and laboratory features of leukemias at the time of diagnosis: an analysis of 1,004 consecutive patients. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org./10.1002/ajh.22100
Description	To determine the major presenting features of the most frequent leukemias and to describe the period from the first symptoms to the final diagnosis, we analyzed the records of 1,004 consecutive patients with acute (AL) and chronic (CL) leukemias diagnosed between 2004 and 2009. In 24% of AL and 63% of CL, the diagnosis was made incidentally. In contrast to the frequency of the symptoms, their spectrum did not differ from historical studies, and fatigue and weakness were the most frequent symptoms observed [with the exception of acute promyelocytic leukemia (APL) where bleeding predominated]. More profound cytopenia was found in AL compared to CL. The median time from the first symptoms to final diagnosis was 3 weeks in AL and 4 weeks in CL. APL had the shortest time to a definitive diagnosis (2 weeks); however, a very short duration of symptoms was also observed in CML (3 weeks). This study is the largest series reported to date on symptoms in leukemia patients at the time of diagnosis To determine the major presenting features of the most frequent leukemias and to describe the period from the first symptoms to the final diagnosis, we analyzed the records of 1,004 consecutive patients with acute (AL) and chronic (CL) leukemias diagnosed between 2004 and 2009. In 24% of AL and 63% of CL, the diagnosis was made incidentally. In contrast to the frequency of the symptoms, their spectrum did not differ from historical studies, and fatigue and weakness were the most frequent symptoms observed [with the exception of acute promyelocytic leukemia (APL) where bleeding predominated]. More profound cytopenia was found in AL compared to CL. The median time from the first symptoms to final diagnosis was 3 weeks in AL and 4 weeks in CL. APL had the shortest time to a definitive diagnosis (2 weeks); however, a very short duration of symptoms was also observed in CML (3 weeks). This study is the largest series reported to date on symptoms in leukemia patients at the time of diagnosis (en)
Title	Clinical and laboratory features of leukemias at the time of diagnosis: an analysis of 1,004 consecutive patients. Clinical and laboratory features of leukemias at the time of diagnosis: an analysis of 1,004 consecutive patients. (en)
skos:prefLabel	Clinical and laboratory features of leukemias at the time of diagnosis: an analysis of 1,004 consecutive patients. Clinical and laboratory features of leukemias at the time of diagnosis: an analysis of 1,004 consecutive patients. (en)
skos:notation	RIV/00023736:_____/11:00009282!RIV12-MZ0-00023736
http://linked.open...avai/riv/aktivita	V Z
http://linked.open...avai/riv/aktivity	V, Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Cetkovský, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	190607
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/11:00009282
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	clinical laboratory features; leukemia diagnosis; leukemia (en)
http://linked.open.../riv/klicoveSlovo	clinical laboratory features leukemia leukemia diagnosis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EBDD11A4B263]
http://linked.open...i/riv/nazevZdroje	American Journal of Hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	86
http://linked.open...iv/tvurceVysledku	Brejcha, M. Burešová, L. Cetkovský, Petr Mayer, J. Procházková, J. Ráčil, Z. Rázga, F. Timilsina, S. Tošková, M. Zounar, R.
http://linked.open...ain/vavai/riv/wos	000295003800019
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0361-8609
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ajh.22100

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