About: The evaluation of survival and proliferation of lymphocytes in autologous mixed leukocyte reaction with dendritic cells. The comparison of incorporation of 3H-thymidine and differential gating method

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About: The evaluation of survival and proliferation of lymphocytes in autologous mixed leukocyte reaction with dendritic cells. The comparison of incorporation of 3H-thymidine and differential gating method Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.cellimm.2011.06.006
Description	Dendritic cells (DCs) play the key role in T-lymphocyte proliferation and induction of antitumour response. The mixed leukocyte reaction (MLR) of T-lymphocytes and DCs is essential instrument for immunological mechanisms studies. Conventionally used method for determination of T-lymphocytes proliferation, 3H-thymidine incorporation, provides only general information. The method of flow cytometry and differential gating, based on time limited acquisition of events and on its distribution according to forward and side scatter values, seems to be more suitable for quantitative and qualitative analysis of T-lymphocyte proliferation. We decided to compare these methods and determine mutual correlation and compatibility. Eleven patients were studied. Both methods retained consistency with regard to survival and proliferation of lymphocytes. However, the correlation was not convincing. Therefore, both methods might be used for evaluation of MLR, but each of them gives specific and complementary information. Dendritic cells (DCs) play the key role in T-lymphocyte proliferation and induction of antitumour response. The mixed leukocyte reaction (MLR) of T-lymphocytes and DCs is essential instrument for immunological mechanisms studies. Conventionally used method for determination of T-lymphocytes proliferation, 3H-thymidine incorporation, provides only general information. The method of flow cytometry and differential gating, based on time limited acquisition of events and on its distribution according to forward and side scatter values, seems to be more suitable for quantitative and qualitative analysis of T-lymphocyte proliferation. We decided to compare these methods and determine mutual correlation and compatibility. Eleven patients were studied. Both methods retained consistency with regard to survival and proliferation of lymphocytes. However, the correlation was not convincing. Therefore, both methods might be used for evaluation of MLR, but each of them gives specific and complementary information. (en)
Title	The evaluation of survival and proliferation of lymphocytes in autologous mixed leukocyte reaction with dendritic cells. The comparison of incorporation of 3H-thymidine and differential gating method The evaluation of survival and proliferation of lymphocytes in autologous mixed leukocyte reaction with dendritic cells. The comparison of incorporation of 3H-thymidine and differential gating method (en)
skos:prefLabel	The evaluation of survival and proliferation of lymphocytes in autologous mixed leukocyte reaction with dendritic cells. The comparison of incorporation of 3H-thymidine and differential gating method The evaluation of survival and proliferation of lymphocytes in autologous mixed leukocyte reaction with dendritic cells. The comparison of incorporation of 3H-thymidine and differential gating method (en)
skos:notation	RIV/00023736:_____/11:00009277!RIV12-MZ0-00023736
http://linked.open...avai/riv/aktivita	I S Z
http://linked.open...avai/riv/aktivity	I, S, Z(MSM0021620808), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Doležalová, Ludmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	198372
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/11:00009277
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	flow cytometry; 3H-thymidine incorporation; differential gating; expression of activation marker; T-lymphocyte proliferation (en)
http://linked.open.../riv/klicoveSlovo	3H-thymidine incorporation T-lymphocyte proliferation differential gating expression of activation marker flow cytometry
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[4F401DEB8B78]
http://linked.open...i/riv/nazevZdroje	Cellular Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	271
http://linked.open...iv/tvurceVysledku	Trněný, M. Doležalová, Ludmila Marečková, H. Pytlík, R. Rychtrmocová, H. Veselá, R.
http://linked.open...ain/vavai/riv/wos	000297658400012
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	0008-8749
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.cellimm.2011.06.006

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