About: Differential expression of microRNAs in CD34+ cells of 5q- syndrome     Goto   Sponge   NotDistinct   Permalink

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Description
  • MicroRNAs (miRNAs) are important regulators of hematopoiesis and their aberrant expression was detected in some clonal hematopoietic disorders. We thus analyzed miRNA expressions in bone marrow CD34+ cells of 5q- syndrome patients. within the 5q deletion. Using microarrays we identified 21 differently expressed miRNAs in 5q- patients compared to controls. Especially, miR-34a was markedly overexpressed in 5q- patients, suggesting its role in an increased apoptosis of bone marrow progenitors
  • MicroRNAs (miRNAs) are important regulators of hematopoiesis and their aberrant expression was detected in some clonal hematopoietic disorders. We thus analyzed miRNA expressions in bone marrow CD34+ cells of 5q- syndrome patients. within the 5q deletion. Using microarrays we identified 21 differently expressed miRNAs in 5q- patients compared to controls. Especially, miR-34a was markedly overexpressed in 5q- patients, suggesting its role in an increased apoptosis of bone marrow progenitors (en)
Title
  • Differential expression of microRNAs in CD34+ cells of 5q- syndrome
  • Differential expression of microRNAs in CD34+ cells of 5q- syndrome (en)
skos:prefLabel
  • Differential expression of microRNAs in CD34+ cells of 5q- syndrome
  • Differential expression of microRNAs in CD34+ cells of 5q- syndrome (en)
skos:notation
  • RIV/00023736:_____/11:00009168!RIV12-MZ0-00023736
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP301/09/P579), V, Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
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  • 194589
http://linked.open...ai/riv/idVysledku
  • RIV/00023736:_____/11:00009168
http://linked.open...riv/jazykVysledku
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  • microRNA; CD34+ cells; 5q- syndrome (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [CE220A5D9771]
http://linked.open...i/riv/nazevZdroje
  • Journal of Hematology & Oncology
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  • 4
http://linked.open...iv/tvurceVysledku
  • Beličková, Monika
  • Dostálová Merkerová, Michaela
  • Grmanová, M.
  • Neuwirtová, R.
  • Vašíková, Alžběta
  • Votavová, Hana
  • Čermák, Jaroslav
http://linked.open...ain/vavai/riv/wos
  • 000286527700001
http://linked.open...n/vavai/riv/zamer
issn
  • 1756-8722
number of pages
http://bibframe.org/vocab/doi
  • 10.1186/1756-8722-4-1
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