About: MicroRNA-451 in chronic myeloid leukemia: miR-451–BCR-ABL regulatory loop?     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:seeAlso
Description
  • Chronic myeloid leukemia (CML) is caused by constituve activity of BCR-ABL tyrosine kinase. Despite of high efficiency of imatinib, selective BCR-ABL inhibitor, about 30% of patients develop resistance. Novel markers and targets for therapy are thus necessary. MicroRNAs are small intereference RNAs whose role in physiological and malignant hematopoiesis has been shown. This study is focused on miR-451 in CML. Following our observation of miR-451 downregulation in CML, we further show its relation to BCR-ABL activity. Our data together with current literature indicate a more complex relationship of miR-451 and BCR-ABL in CML.
  • Chronic myeloid leukemia (CML) is caused by constituve activity of BCR-ABL tyrosine kinase. Despite of high efficiency of imatinib, selective BCR-ABL inhibitor, about 30% of patients develop resistance. Novel markers and targets for therapy are thus necessary. MicroRNAs are small intereference RNAs whose role in physiological and malignant hematopoiesis has been shown. This study is focused on miR-451 in CML. Following our observation of miR-451 downregulation in CML, we further show its relation to BCR-ABL activity. Our data together with current literature indicate a more complex relationship of miR-451 and BCR-ABL in CML. (en)
Title
  • MicroRNA-451 in chronic myeloid leukemia: miR-451–BCR-ABL regulatory loop?
  • MicroRNA-451 in chronic myeloid leukemia: miR-451–BCR-ABL regulatory loop? (en)
skos:prefLabel
  • MicroRNA-451 in chronic myeloid leukemia: miR-451–BCR-ABL regulatory loop?
  • MicroRNA-451 in chronic myeloid leukemia: miR-451–BCR-ABL regulatory loop? (en)
skos:notation
  • RIV/00023736:_____/11:00009163!RIV12-MZ0-00023736
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 212342
http://linked.open...ai/riv/idVysledku
  • RIV/00023736:_____/11:00009163
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • CML; miRNA; miR-451; BCR-ABL kinase; Imatinib; cell cultivation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [EE7CC8CECECC]
http://linked.open...i/riv/nazevZdroje
  • Leukemia Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 35
http://linked.open...iv/tvurceVysledku
  • Klamová, Hana
  • Moravcová, Jana
  • Lopotová, Tereza
  • Žáčková, Markéta
http://linked.open...ain/vavai/riv/wos
  • 000291470800042
http://linked.open...n/vavai/riv/zamer
issn
  • 0145-2126
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.leukres.2011.03.029
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software