About: Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3)

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About: Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3) Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Protein arginine methyltransferase 3 (PRMT3) is a cytosolic enzyme that catalyzes the formation of mono- and asymmetric dimethyl arginines, with ribosomal protein (RP) S2 as its main in vivo substrate. Defects in ribosome maturation are the hallmark of Diamond-Blackfan anemia (DBA). Sequencing of the PRMT3 gene in patients from the Czech DBA registry revealed a heterozygous mutation encoding the Tyr87Cys substitution. Although later analysis excluded this mutation as the cause of DBA in the patient, we anticipated that this substitution might be important for PRMT3 function. Indeed, biochemical analyses showed the importance of Tyr87 for the interaction between PRMT3 and RPS2 and for its full enzymatic activity Protein arginine methyltransferase 3 (PRMT3) is a cytosolic enzyme that catalyzes the formation of mono- and asymmetric dimethyl arginines, with ribosomal protein (RP) S2 as its main in vivo substrate. Defects in ribosome maturation are the hallmark of Diamond-Blackfan anemia (DBA). Sequencing of the PRMT3 gene in patients from the Czech DBA registry revealed a heterozygous mutation encoding the Tyr87Cys substitution. Although later analysis excluded this mutation as the cause of DBA in the patient, we anticipated that this substitution might be important for PRMT3 function. Indeed, biochemical analyses showed the importance of Tyr87 for the interaction between PRMT3 and RPS2 and for its full enzymatic activity (en)
Title	Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3) Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3) (en)
skos:prefLabel	Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3) Tyrosine 87 is vital for the activity of human protein arginine methyltransferase 3 (PRMT3) (en)
skos:notation	RIV/00023736:_____/11:00008920!RIV11-MZ0-00023736
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06044), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Petrák, Jiří Handrková, Helena Čmejla, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	236424
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/11:00008920
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PRMT3; RPS2; methylation; Diamond-Blackfan anemia; DBA (en)
http://linked.open.../riv/klicoveSlovo	DBA PRMT3 RPS2 methylation Diamond-Blackfan anemia
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[CF8D07982F93]
http://linked.open...i/riv/nazevZdroje	Biochimica et Biophysica Acta, Complete Edition
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Experimental Hematology
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	1814
http://linked.open...iv/tvurceVysledku	Halada, P. Petrák, Jiří Pospíšilová, D. Handrková, Helena Čmejla, Radek
http://linked.open...ain/vavai/riv/wos	000287067700002
http://linked.open...n/vavai/riv/zamer	Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	0006-3002
number of pages	6 (xsd:int)

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