About: Adoptive immunotherapy, chemotherapy, and second allogeneic transplant in the treatment of post-transplant relapse of acute leukemia in children : a single center experience

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About: Adoptive immunotherapy, chemotherapy, and second allogeneic transplant in the treatment of post-transplant relapse of acute leukemia in children : a single center experience Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Relapse of acute leukemia (AL) remains a major cause of treatment failure in allogeneic hematopoietic stem cell transplantation (HSCT) in children. Current treatment options include chemotherapy (CHT), adoptive immunotherapy (AI) and second allogeneic transplantation. Between January 1994 and December 2007 a total of 132 children with acute leukemia were transplanted at our institution. Post-transplant relapse of AL following first allogeneic HSCT was documented in 42 patients, intensive treatment of hematological relapse was initiated in 20 patients. Twelve patients underwent second allogeneic HSCT. We showed that second HSCT in pediatric patients was well tolerated and that it is a reasonable option for the treatment of children with relapse of acute leukemia after the first allogeneic transplant. Relapse of acute leukemia (AL) remains a major cause of treatment failure in allogeneic hematopoietic stem cell transplantation (HSCT) in children. Current treatment options include chemotherapy (CHT), adoptive immunotherapy (AI) and second allogeneic transplantation. Between January 1994 and December 2007 a total of 132 children with acute leukemia were transplanted at our institution. Post-transplant relapse of AL following first allogeneic HSCT was documented in 42 patients, intensive treatment of hematological relapse was initiated in 20 patients. Twelve patients underwent second allogeneic HSCT. We showed that second HSCT in pediatric patients was well tolerated and that it is a reasonable option for the treatment of children with relapse of acute leukemia after the first allogeneic transplant. (en)
Title	Adoptive immunotherapy, chemotherapy, and second allogeneic transplant in the treatment of post-transplant relapse of acute leukemia in children : a single center experience Adoptive immunotherapy, chemotherapy, and second allogeneic transplant in the treatment of post-transplant relapse of acute leukemia in children : a single center experience (en)
skos:prefLabel	Adoptive immunotherapy, chemotherapy, and second allogeneic transplant in the treatment of post-transplant relapse of acute leukemia in children : a single center experience Adoptive immunotherapy, chemotherapy, and second allogeneic transplant in the treatment of post-transplant relapse of acute leukemia in children : a single center experience (en)
skos:notation	RIV/00023736:_____/10:00008927!RIV11-MZ0-00023736
http://linked.open...avai/riv/aktivita	I V Z
http://linked.open...avai/riv/aktivity	I, V, Z(MZ0FNM2005)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Říhová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	245474
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/10:00008927
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acute leukemia; second allogeneic HSCT; relapse; childhood (en)
http://linked.open.../riv/klicoveSlovo	acute leukemia relapse childhood second allogeneic HSCT
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B6E99244A889]
http://linked.open...i/riv/nazevZdroje	Leukemia and Lymphoma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	51
http://linked.open...iv/tvurceVysledku	Sedláček, P. Keslová, P. Starý, J. Formánková, R. Žižková, Hana Šrámková, I.
http://linked.open...ain/vavai/riv/wos	000282895200028
http://linked.open...n/vavai/riv/zamer	Zdokonalení časné diagnostiky, prevence a léčby těžkých vrozených vývojových vad a chorob geneticky podmíněných či s genetickou dispozicí v prenatální a postnatální fázi vývoje
issn	1042-8194
number of pages	5 (xsd:int)

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