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Description
| - Relapse of acute leukemia (AL) remains a major cause of treatment failure in allogeneic hematopoietic stem cell transplantation (HSCT) in children. Current treatment options include chemotherapy (CHT), adoptive immunotherapy (AI) and second allogeneic transplantation. Between January 1994 and December 2007 a total of 132 children with acute leukemia were transplanted at our institution. Post-transplant relapse of AL following first allogeneic HSCT was documented in 42 patients, intensive treatment of hematological relapse was initiated in 20 patients. Twelve patients underwent second allogeneic HSCT. We showed that second HSCT in pediatric patients was well tolerated and that it is a reasonable option for the treatment of children with relapse of acute leukemia after the first allogeneic transplant.
- Relapse of acute leukemia (AL) remains a major cause of treatment failure in allogeneic hematopoietic stem cell transplantation (HSCT) in children. Current treatment options include chemotherapy (CHT), adoptive immunotherapy (AI) and second allogeneic transplantation. Between January 1994 and December 2007 a total of 132 children with acute leukemia were transplanted at our institution. Post-transplant relapse of AL following first allogeneic HSCT was documented in 42 patients, intensive treatment of hematological relapse was initiated in 20 patients. Twelve patients underwent second allogeneic HSCT. We showed that second HSCT in pediatric patients was well tolerated and that it is a reasonable option for the treatment of children with relapse of acute leukemia after the first allogeneic transplant. (en)
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Title
| - Adoptive immunotherapy, chemotherapy, and second allogeneic transplant in the treatment of post-transplant relapse of acute leukemia in children : a single center experience
- Adoptive immunotherapy, chemotherapy, and second allogeneic transplant in the treatment of post-transplant relapse of acute leukemia in children : a single center experience (en)
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skos:prefLabel
| - Adoptive immunotherapy, chemotherapy, and second allogeneic transplant in the treatment of post-transplant relapse of acute leukemia in children : a single center experience
- Adoptive immunotherapy, chemotherapy, and second allogeneic transplant in the treatment of post-transplant relapse of acute leukemia in children : a single center experience (en)
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skos:notation
| - RIV/00023736:_____/10:00008927!RIV11-MZ0-00023736
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00023736:_____/10:00008927
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - acute leukemia; second allogeneic HSCT; relapse; childhood (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Sedláček, P.
- Keslová, P.
- Starý, J.
- Formánková, R.
- Žižková, Hana
- Šrámková, I.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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