About: Advanced Rai stage in patients with chronic lymphotic leukaemia correlates with simultaneous hypermethylation of plural tumour suppressor genes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Hypermethylation of CpG islands within gene promoters is one of various mechanisms of gene silencing involved in the pathogenesis of human cancer. By using methylation-specific polymerase chain reaction we explored aberrant promoter methylation of five tumour suppressor genes in 29 patients with chronic lymphocytic leukaemia. Aberrant methylation of DLC1, SHP1, p15 and p16 occurred, respectively, in 89.7 %, 70 %, 62.1 % and 31 % of patients at diagnosis. Lamin A/C was unmethylated in all the samples. Hypermethylation of at least one gene was detected in 96.6 % of patients. Concurrent methylation of two or more genes correlated with Rai stage at diagnosis. Hypermethylation of CpG islands within gene promoters is one of various mechanisms of gene silencing involved in the pathogenesis of human cancer. By using methylation-specific polymerase chain reaction we explored aberrant promoter methylation of five tumour suppressor genes in 29 patients with chronic lymphocytic leukaemia. Aberrant methylation of DLC1, SHP1, p15 and p16 occurred, respectively, in 89.7 %, 70 %, 62.1 % and 31 % of patients at diagnosis. Lamin A/C was unmethylated in all the samples. Hypermethylation of at least one gene was detected in 96.6 % of patients. Concurrent methylation of two or more genes correlated with Rai stage at diagnosis. (en)
Title	Advanced Rai stage in patients with chronic lymphotic leukaemia correlates with simultaneous hypermethylation of plural tumour suppressor genes Advanced Rai stage in patients with chronic lymphotic leukaemia correlates with simultaneous hypermethylation of plural tumour suppressor genes (en)
skos:prefLabel	Advanced Rai stage in patients with chronic lymphotic leukaemia correlates with simultaneous hypermethylation of plural tumour suppressor genes Advanced Rai stage in patients with chronic lymphotic leukaemia correlates with simultaneous hypermethylation of plural tumour suppressor genes (en)
skos:notation	RIV/00023736:_____/10:00008723!RIV11-MZ0-00023736
http://linked.open...avai/riv/aktivita	I V Z
http://linked.open...avai/riv/aktivity	I, V, Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Schwarz, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	245521
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/10:00008723
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chronic lymphotic leukaemia; aberrant hypermethylation; tumour-suppressor gene; Rai stage; methylation-specific polymerase chain reaction (en)
http://linked.open.../riv/klicoveSlovo	Rai stage aberrant hypermethylation chronic lymphotic leukaemia methylation-specific polymerase chain reaction tumour-suppressor gene
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[5BD5E81F0E71]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Karban, J. Trněný, M. Štuka, Č. Schwarz, Jiří Votavová, H. Forsterová, K.
http://linked.open...ain/vavai/riv/wos	000281924500003
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	0015-5500
number of pages	7 (xsd:int)

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