About: Interaction of blood plasma with antifouling surfaces

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nonspecific adsorption of proteins is a crucial problem in the detection of analytes in complex biological media by affinity sensors operating with label-free detection. We modified the gold surface of surface plasmon resonance (SPR) sensors with three types of promising antifouling coatings: self-assembled monolayers (SAM)s of alkanethiolates terminated with diethylene glycol and carboxylic groups, poly(ethylene glycol) grafted onto the SAMs, and zwitterionic polymer brushes of poly(carboxybetaine methacrylate) poly(CBMA), poly(sulfobetaine methacrylate), and poly(phosphorylcholine methacrylate). Neither high surface wettability nor zero adsorption of the main plasma proteins - serum albumin, IgG, and fibrinogen, were sufficient conditions to prevent fouling from blood plasma. Plasma deposition was completely prevented only by poly(CBMA) brushes. Nonspecific adsorption of proteins is a crucial problem in the detection of analytes in complex biological media by affinity sensors operating with label-free detection. We modified the gold surface of surface plasmon resonance (SPR) sensors with three types of promising antifouling coatings: self-assembled monolayers (SAM)s of alkanethiolates terminated with diethylene glycol and carboxylic groups, poly(ethylene glycol) grafted onto the SAMs, and zwitterionic polymer brushes of poly(carboxybetaine methacrylate) poly(CBMA), poly(sulfobetaine methacrylate), and poly(phosphorylcholine methacrylate). Neither high surface wettability nor zero adsorption of the main plasma proteins - serum albumin, IgG, and fibrinogen, were sufficient conditions to prevent fouling from blood plasma. Plasma deposition was completely prevented only by poly(CBMA) brushes. (en)
Title	Interaction of blood plasma with antifouling surfaces Interaction of blood plasma with antifouling surfaces (en)
skos:prefLabel	Interaction of blood plasma with antifouling surfaces Interaction of blood plasma with antifouling surfaces (en)
skos:notation	RIV/00023736:_____/09:00008438!RIV10-MZ0-00023736
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(KAN200670701), Z(AV0Z40500505), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Riedel, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	319896
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/09:00008438
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	blood plasma fouling; antigouling coatings; SPR biosensors (en)
http://linked.open.../riv/klicoveSlovo	SPR biosensors antigouling coatings blood plasma fouling
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DF898F0C9855]
http://linked.open...i/riv/nazevZdroje	Langmuir : the ACS Journal of Surfaces and Colloids
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Surface plasmon resonance biosensors and protein arrays for medical diagnostics
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Brynda, E. Riedel, Tomáš Houska, M. Rodriguez Emmenegger, C. Sedláková, Z. Alles, A. B.
http://linked.open...ain/vavai/riv/wos	000266604000046
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	0743-7463
number of pages	6 (xsd:int)

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