About: The results of allogeneic transplants in patients with malignant lymphoma-a retrospective analysis of data from the Czech National Registry

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About: The results of allogeneic transplants in patients with malignant lymphoma-a retrospective analysis of data from the Czech National Registry Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We processed data of 79 patients (pts) with malignant lymphoma from the National Registry of haematopoietic stem cell transplants conducted between 1997 and 2006. The haematopoietic stem cell donor in 48 pts was an HLA matched relative, and in 31 pts an unrelated volunteer. Sixty (77%) pts were transplanted with reduced intensity conditioning (RIC), eleven (23%) pts with myeloablative conditioning (MC). Acute graft-versus-host disease (aGVHD) was recorded in 26 (33%) pts. Chronic GVHD was diagnosed in 19 (36%) of the 53 assessable pts. Transplant-related mortality (TRM) in the first 100 days, 1 year and 3 years for the whole group was 26%, 33% and 33%. Twenty (26%) of the pts relapsed. During the median follow-up of 26 months the overall survival (OS) was 44%, the progression free survival (PFS) was 54% and cumulative incidence of relapse was 45%. Pts with chemoresistant disease had significantly worse results (OS at 3 years 22% vs. 56%, p=0.002). We processed data of 79 patients (pts) with malignant lymphoma from the National Registry of haematopoietic stem cell transplants conducted between 1997 and 2006. The haematopoietic stem cell donor in 48 pts was an HLA matched relative, and in 31 pts an unrelated volunteer. Sixty (77%) pts were transplanted with reduced intensity conditioning (RIC), eleven (23%) pts with myeloablative conditioning (MC). Acute graft-versus-host disease (aGVHD) was recorded in 26 (33%) pts. Chronic GVHD was diagnosed in 19 (36%) of the 53 assessable pts. Transplant-related mortality (TRM) in the first 100 days, 1 year and 3 years for the whole group was 26%, 33% and 33%. Twenty (26%) of the pts relapsed. During the median follow-up of 26 months the overall survival (OS) was 44%, the progression free survival (PFS) was 54% and cumulative incidence of relapse was 45%. Pts with chemoresistant disease had significantly worse results (OS at 3 years 22% vs. 56%, p=0.002). (en)
Title	The results of allogeneic transplants in patients with malignant lymphoma-a retrospective analysis of data from the Czech National Registry The results of allogeneic transplants in patients with malignant lymphoma-a retrospective analysis of data from the Czech National Registry (en)
skos:prefLabel	The results of allogeneic transplants in patients with malignant lymphoma-a retrospective analysis of data from the Czech National Registry The results of allogeneic transplants in patients with malignant lymphoma-a retrospective analysis of data from the Czech National Registry (en)
skos:notation	RIV/00023736:_____/09:00008286!RIV10-MZ0-00023736
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(NR8223), V
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Benešová, Kateřina Válková, Veronika Vítek, Antonín
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	339206
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/09:00008286
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lymphoma; allogeneic; transplantations; GvHD (en)
http://linked.open.../riv/klicoveSlovo	transplantations lymphoma allogeneic GvHD
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[92F18B9E8D4A]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of transplantation activities, indications and results in the Czech Republic - National Stem Cell Transplantation Registry.
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Faber, E. Mayer, J. Trněný, M. Žák, P. Benešová, Kateřina Válková, Veronika Vítek, Antonín
http://linked.open...ain/vavai/riv/wos	000262614200013
issn	0028-2685
number of pages	8 (xsd:int)

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