About: Isolation and properties of gene-modified mouse bcr-abl-transformed cells expressing various immunostimulatory factors

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	B210 cells are murine (BALB/c) cells transformed by bcr-abl fusion gene. After intravenous administration they are capable of inducing leukaemia–like disease in syngeneic mice. From these cells a thymidine–kinase less subline was derived.It was significantly less pathogenic than the parental cells. However, a highly pathogenic clone denoted B210cTK-/cl-2 was isolated from its population. As determined by Western blotting, these cells produced more p210bcr-abl protein than the parental B210 cells. To successfully transfect these cells a modified electroporation method was introduced. B210 cells are murine (BALB/c) cells transformed by bcr-abl fusion gene. After intravenous administration they are capable of inducing leukaemia–like disease in syngeneic mice. From these cells a thymidine–kinase less subline was derived.It was significantly less pathogenic than the parental cells. However, a highly pathogenic clone denoted B210cTK-/cl-2 was isolated from its population. As determined by Western blotting, these cells produced more p210bcr-abl protein than the parental B210 cells. To successfully transfect these cells a modified electroporation method was introduced. (en)
Title	Isolation and properties of gene-modified mouse bcr-abl-transformed cells expressing various immunostimulatory factors Isolation and properties of gene-modified mouse bcr-abl-transformed cells expressing various immunostimulatory factors (en)
skos:prefLabel	Isolation and properties of gene-modified mouse bcr-abl-transformed cells expressing various immunostimulatory factors Isolation and properties of gene-modified mouse bcr-abl-transformed cells expressing various immunostimulatory factors (en)
skos:notation	RIV/00023736:_____/09:00008210!RIV10-MZ0-00023736
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Dušková, Martina Jinoch, Pavel Vonka, Vladimír Sobotková, Eva Petráčková, Martina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	320505
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/09:00008210
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CML; BCR-ABL; HSV TK; cytokines; gene-modified tumour cells; pathogenicity (en)
http://linked.open.../riv/klicoveSlovo	CML gene-modified tumour cells cytokines BCR-ABL HSV TK pathogenicity
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[032AC5C38E6A]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Sobotková, Eva Jinoch, Pavel Vonka, Vladimír Dušková, Martina Petráčková, Martina
http://linked.open...ain/vavai/riv/wos	000265622200003
http://linked.open...n/vavai/riv/zamer	Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	0028-2685
number of pages	8 (xsd:int)

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