About: Folic acid does not improve surrogate markers of early atherosclerosis in atorvastatin-treated patients

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About: Folic acid does not improve surrogate markers of early atherosclerosis in atorvastatin-treated patients Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We examined the expression of l-selectin (CD62L); ?-subunits of integrins LFA-1 (CD11a), Mac-1 (CD11b), and VLA-4 (CD49d); and ß-subunit of ß-2 integrins (CD18) by an immunofluorescence method using single-step staining of whole blood with monoclonal antibodies. The fluorescence was quantified by flow cytometry. Reactivity of the forearm skin microvascular bed to thermal and ischemic stimuli was measured using laser Doppler flowmetry. Postocclusive and thermal reactive hyperemia tests were performed. Statistical analysis used 2-sample t test and paired t test. Homocysteine levels decreased significantly in the folic acid–treated group (11.78 2.7 vs 9.75 1.89 µmol/L, P < .0001) but did not change in the control group (11.17 2.09 vs 11.88 2.88 µmol/L). There was no effect of folic acid treatment on leukocyte expression of cell adhesion molecules or microvascular reactivity. The lack of effect of folic acid on microvascular reactivity and leukocyte adhesion molecules supports the We examined the expression of l-selectin (CD62L); ?-subunits of integrins LFA-1 (CD11a), Mac-1 (CD11b), and VLA-4 (CD49d); and ß-subunit of ß-2 integrins (CD18) by an immunofluorescence method using single-step staining of whole blood with monoclonal antibodies. The fluorescence was quantified by flow cytometry. Reactivity of the forearm skin microvascular bed to thermal and ischemic stimuli was measured using laser Doppler flowmetry. Postocclusive and thermal reactive hyperemia tests were performed. Statistical analysis used 2-sample t test and paired t test. Homocysteine levels decreased significantly in the folic acid–treated group (11.78 2.7 vs 9.75 1.89 µmol/L, P < .0001) but did not change in the control group (11.17 2.09 vs 11.88 2.88 µmol/L). There was no effect of folic acid treatment on leukocyte expression of cell adhesion molecules or microvascular reactivity. The lack of effect of folic acid on microvascular reactivity and leukocyte adhesion molecules supports the (en) Cílem studie bylo prozkoumat vliv kyseliny listové na terapii statiny u (cs)
Title	Folic acid does not improve surrogate markers of early atherosclerosis in atorvastatin-treated patients Kyselina listová nezlepšuje markery časné aterosklerózy u pacientů na (cs) Folic acid does not improve surrogate markers of early atherosclerosis in atorvastatin-treated patients (en)
skos:prefLabel	Folic acid does not improve surrogate markers of early atherosclerosis in atorvastatin-treated patients Kyselina listová nezlepšuje markery časné aterosklerózy u pacientů na (cs) Folic acid does not improve surrogate markers of early atherosclerosis in atorvastatin-treated patients (en)
skos:notation	RIV/00023736:_____/07:00007433!RIV08-MZ0-00023736
http://linked.open.../vavai/riv/strany	181;185
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Marinov, Iuri
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	422290
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/07:00007433
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	human; hyperhomocysteinemia; folic acid; hypercholesterolemia; adhesion molecules; microvascular reactivity; endothelial dysfunction (en)
http://linked.open.../riv/klicoveSlovo	hypercholesterolemia microvascular reactivity human endothelial dysfunction folic acid adhesion molecules hyperhomocysteinemia
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8398B177AA1D]
http://linked.open...i/riv/nazevZdroje	Nutrition Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Marinov, Iuri Šimek, J. Malík, J. Vráblík, M. Češka, R. Štulc, T. Svobodová, H. Kasalová, Z. Žídková, K.
issn	0271-5317
number of pages	5 (xsd:int)

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