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Description
| - Zvýšená exprese JNK2 a p38 MAPK byla publikována u chronické myeloidní leukemie (CML). V této studii byl testován vliv suprese JNK2/p38 na expresní profil CML buněčných linií. Několik genů spojených s buněčnou transformací vykazovalo signifikantní změny v expresi po inhibici JNK2/p38. Dále, pozorování, že ani JNK2 ani p38-siRNA transfekce nevede k významné změně proliferace těchto buněk, naznačuje, že inhibice genu JNK2, nebo p38 MAPK není dostatečná pro zástavu buněčného dělení u CML. (cs)
- Over-expression of JNK2 and p38 MAPK has been already observed in chronic myeloid leukemia (CML). In the present study, impacts of JNK2/p38 suppression on gene expression profile of CML cell lines were studied. After JNK2 or p38 siRNA-mediated depletion, several genes connected to cancer processes showed significant expression changes. The observation that neither JNK2 nor p38 siRNA-mediated inhibition led to significant change of CML cell proliferation suggests that there are other important, likely up-stream regulators essential for CML malignant cell growth/transformation; therefore, separate inhibition of JNK2 or p38 MAPK gene is not sufficient for a proliferation arrest.
- Over-expression of JNK2 and p38 MAPK has been already observed in chronic myeloid leukemia (CML). In the present study, impacts of JNK2/p38 suppression on gene expression profile of CML cell lines were studied. After JNK2 or p38 siRNA-mediated depletion, several genes connected to cancer processes showed significant expression changes. The observation that neither JNK2 nor p38 siRNA-mediated inhibition led to significant change of CML cell proliferation suggests that there are other important, likely up-stream regulators essential for CML malignant cell growth/transformation; therefore, separate inhibition of JNK2 or p38 MAPK gene is not sufficient for a proliferation arrest. (en)
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Title
| - JNK2 and p38 MAPK over-expressions do not represent key events in chronic myeloid leukemia transformation
- Zvýšená exprese JNK2 a p38 MAPK nepředstavuje klíčovou událost pro transformaci u chronické myeloidní leukemie (cs)
- JNK2 and p38 MAPK over-expressions do not represent key events in chronic myeloid leukemia transformation (en)
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skos:prefLabel
| - JNK2 and p38 MAPK over-expressions do not represent key events in chronic myeloid leukemia transformation
- Zvýšená exprese JNK2 a p38 MAPK nepředstavuje klíčovou událost pro transformaci u chronické myeloidní leukemie (cs)
- JNK2 and p38 MAPK over-expressions do not represent key events in chronic myeloid leukemia transformation (en)
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skos:notation
| - RIV/00023736:_____/07:00007214!RIV08-MZ0-00023736
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00023736:_____/07:00007214
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - CML; expression arrays; siRNA; JNK2; MAPK; p38 (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...in/vavai/riv/obor
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brdička, Radim
- Merkerová, Michaela
- Bruchová, Hana
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