About: JNK2 and p38 MAPK over-expressions do not represent key events in chronic myeloid leukemia transformation     Goto   Sponge   NotDistinct   Permalink

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  • Zvýšená exprese JNK2 a p38 MAPK byla publikována u chronické myeloidní leukemie (CML). V této studii byl testován vliv suprese JNK2/p38 na expresní profil CML buněčných linií. Několik genů spojených s buněčnou transformací vykazovalo signifikantní změny v expresi po inhibici JNK2/p38. Dále, pozorování, že ani JNK2 ani p38-siRNA transfekce nevede k významné změně proliferace těchto buněk, naznačuje, že inhibice genu JNK2, nebo p38 MAPK není dostatečná pro zástavu buněčného dělení u CML. (cs)
  • Over-expression of JNK2 and p38 MAPK has been already observed in chronic myeloid leukemia (CML). In the present study, impacts of JNK2/p38 suppression on gene expression profile of CML cell lines were studied. After JNK2 or p38 siRNA-mediated depletion, several genes connected to cancer processes showed significant expression changes. The observation that neither JNK2 nor p38 siRNA-mediated inhibition led to significant change of CML cell proliferation suggests that there are other important, likely up-stream regulators essential for CML malignant cell growth/transformation; therefore, separate inhibition of JNK2 or p38 MAPK gene is not sufficient for a proliferation arrest.
  • Over-expression of JNK2 and p38 MAPK has been already observed in chronic myeloid leukemia (CML). In the present study, impacts of JNK2/p38 suppression on gene expression profile of CML cell lines were studied. After JNK2 or p38 siRNA-mediated depletion, several genes connected to cancer processes showed significant expression changes. The observation that neither JNK2 nor p38 siRNA-mediated inhibition led to significant change of CML cell proliferation suggests that there are other important, likely up-stream regulators essential for CML malignant cell growth/transformation; therefore, separate inhibition of JNK2 or p38 MAPK gene is not sufficient for a proliferation arrest. (en)
Title
  • JNK2 and p38 MAPK over-expressions do not represent key events in chronic myeloid leukemia transformation
  • Zvýšená exprese JNK2 a p38 MAPK nepředstavuje klíčovou událost pro transformaci u chronické myeloidní leukemie (cs)
  • JNK2 and p38 MAPK over-expressions do not represent key events in chronic myeloid leukemia transformation (en)
skos:prefLabel
  • JNK2 and p38 MAPK over-expressions do not represent key events in chronic myeloid leukemia transformation
  • Zvýšená exprese JNK2 a p38 MAPK nepředstavuje klíčovou událost pro transformaci u chronické myeloidní leukemie (cs)
  • JNK2 and p38 MAPK over-expressions do not represent key events in chronic myeloid leukemia transformation (en)
skos:notation
  • RIV/00023736:_____/07:00007214!RIV08-MZ0-00023736
http://linked.open.../vavai/riv/strany
  • 503;510
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR7989)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 428214
http://linked.open...ai/riv/idVysledku
  • RIV/00023736:_____/07:00007214
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • CML; expression arrays; siRNA; JNK2; MAPK; p38 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SK - Slovenská republika
http://linked.open...ontrolniKodProRIV
  • [426D7DDB7A17]
http://linked.open...i/riv/nazevZdroje
  • Neoplasma
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 54
http://linked.open...iv/tvurceVysledku
  • Brdička, Radim
  • Merkerová, Michaela
  • Bruchová, Hana
issn
  • 0028-2685
number of pages
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