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rdf:type
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Description
| - Cross-linked ribonuclease A (PS-RNase A) or its covalently linked dimer to polyspermine (PS-dimeric RNase A) were prepared. The in vitro and in vivo cytotoxic activity of PS-RNase A was not higher than that known for free polyspermine. PS-dimeric RNase A, which was characterized by several assays, proved to be a definitely more efficient antitumor agent, both in vitro and in vivo. This result could be explained in view of the importance of positive charges for ribonuclease activity, considering the higher basicity of PS-dimeric RNase A compared to that of PS-(monomeric) RNase A
- Cross-linked ribonuclease A (PS-RNase A) or its covalently linked dimer to polyspermine (PS-dimeric RNase A) were prepared. The in vitro and in vivo cytotoxic activity of PS-RNase A was not higher than that known for free polyspermine. PS-dimeric RNase A, which was characterized by several assays, proved to be a definitely more efficient antitumor agent, both in vitro and in vivo. This result could be explained in view of the importance of positive charges for ribonuclease activity, considering the higher basicity of PS-dimeric RNase A compared to that of PS-(monomeric) RNase A (en)
- Připravili jsme konjugáty polysperminu s ribonukleázou A (PS-RNase A) a jejím kovalentně vázaným dimerem (PS-dimeric RNase A). In vitro a in vivo testovaná cytotoxická aktivita PS-RNasy A nepřesáhla aktivitu samotného polysperminu. Naproti tomu cytotoxická aktivita PS-dimeric RNasy, charakterisované několika způsoby, byla prokazatelně nejvyšší. Tento výsledek by mohl být vysvětlen důležitostí positivních nábojů pro ribonukleázovou aktivitu vzhledem k vyšší basicitě PS-dimeric RNázy v porovnání s konjugátem monomerní RNázy A (cs)
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Title
| - Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A
- Cytotoxický účinek polyspermin –ribonukleasy A a polyspermin-dimeru ribonukleasy A (cs)
- Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A (en)
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skos:prefLabel
| - Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A
- Cytotoxický účinek polyspermin –ribonukleasy A a polyspermin-dimeru ribonukleasy A (cs)
- Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A (en)
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skos:notation
| - RIV/00023736:_____/07:00007198!RIV09-MZ0-00023736
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA521/06/1149), P(GA523/04/0755), Z(AV0Z50450515), Z(MZ0UHKT2005)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00023736:_____/07:00007198
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - antitumor activity; dimeric RNase A; polyspermine conjugates (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Matoušek, J.
- Poučková, P.
- Souček, Josef
- Gotte, G.
- Libonati, M.
- Vottariello, F.
- Laurents, D. V.
- Constanzo, Ch.
- Donadelli, M.
- Morbio, M.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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