About: Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A

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About: Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cross-linked ribonuclease A (PS-RNase A) or its covalently linked dimer to polyspermine (PS-dimeric RNase A) were prepared. The in vitro and in vivo cytotoxic activity of PS-RNase A was not higher than that known for free polyspermine. PS-dimeric RNase A, which was characterized by several assays, proved to be a definitely more efficient antitumor agent, both in vitro and in vivo. This result could be explained in view of the importance of positive charges for ribonuclease activity, considering the higher basicity of PS-dimeric RNase A compared to that of PS-(monomeric) RNase A Cross-linked ribonuclease A (PS-RNase A) or its covalently linked dimer to polyspermine (PS-dimeric RNase A) were prepared. The in vitro and in vivo cytotoxic activity of PS-RNase A was not higher than that known for free polyspermine. PS-dimeric RNase A, which was characterized by several assays, proved to be a definitely more efficient antitumor agent, both in vitro and in vivo. This result could be explained in view of the importance of positive charges for ribonuclease activity, considering the higher basicity of PS-dimeric RNase A compared to that of PS-(monomeric) RNase A (en) Připravili jsme konjugáty polysperminu s ribonukleázou A (PS-RNase A) a jejím kovalentně vázaným dimerem (PS-dimeric RNase A). In vitro a in vivo testovaná cytotoxická aktivita PS-RNasy A nepřesáhla aktivitu samotného polysperminu. Naproti tomu cytotoxická aktivita PS-dimeric RNasy, charakterisované několika způsoby, byla prokazatelně nejvyšší. Tento výsledek by mohl být vysvětlen důležitostí positivních nábojů pro ribonukleázovou aktivitu vzhledem k vyšší basicitě PS-dimeric RNázy v porovnání s konjugátem monomerní RNázy A (cs)
Title	Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A Cytotoxický účinek polyspermin –ribonukleasy A a polyspermin-dimeru ribonukleasy A (cs) Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A (en)
skos:prefLabel	Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A Cytotoxický účinek polyspermin –ribonukleasy A a polyspermin-dimeru ribonukleasy A (cs) Cytotoxicity of polyspermine-ribonuclease A and polyspermine-dimeric ribonuclease A (en)
skos:notation	RIV/00023736:_____/07:00007198!RIV09-MZ0-00023736
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA521/06/1149), P(GA523/04/0755), Z(AV0Z50450515), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Souček, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	415555
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/07:00007198
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antitumor activity; dimeric RNase A; polyspermine conjugates (en)
http://linked.open.../riv/klicoveSlovo	dimeric RNase A polyspermine conjugates antitumor activity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[AAC048CDDB76]
http://linked.open...i/riv/nazevZdroje	Bioconjugate Chemistry
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Biological and antitumor effects of pancreatic ribonuclease A oligomers Molecular analysis of plant nuclease homologues and their antitumor potential in comparison with animal ribonucleases
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Matoušek, J. Poučková, P. Souček, Josef Gotte, G. Libonati, M. Vottariello, F. Laurents, D. V. Constanzo, Ch. Donadelli, M. Morbio, M.
http://linked.open...n/vavai/riv/zamer	Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture Význam molekulárně biologických vyšetření pro objasnění patogeneze a pro diagnostiku poruch krvetvorby a využití krvetvorné buňky v léčbě onemocnění krvetvorby a jiných tkání.
issn	1043-1802
number of pages	9 (xsd:int)

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