About: Bmi-1 over-expression plays a secondary role in chronic myeloid leukemia transformation

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Zvýšená exprese genu Bmi-1 byla prokázána u různých typů rakoviny, což ukazuje, že Bmi-1 by mohl být potenciálním cílem pro jejich terapii. V této publikaci jsme studovali expresi Bmi-1 u chronické myeloidní leukemie (CML) a pomocí qRT-PCR jsme prokázali signifikantně zvýšenou hladinu jeho transkriptu u CML buněk. Pomocí cDNA čipů jsme po siRNA-tlumení exprese Bmi-1 dále detekovali deregulaci několika genů. Dále jsme testovali vliv siRNA-inhibice Bmi-1 genu na CML buněčné linie, avšak změnu v proliferaci buněk jsme nedetekovali. Přestože je Bmi-1 u CML zvýšeně exprimován a jeho produkce je spjata s transformačním procesem, hraje u CML pravděpodobně spíše sekundární úlohu (cs) It has been demonstrated that over-expression of Bmi-1 occurs in variety of cancers, which proposed Bmi-1 as a potential target for therapeutic intervention. In this study, we investigated the role of Bmi-1 in chronic myeloid leukemia (CML). Using qRT-PCR, we demonstrated significantly increased level of Bmi-1 transcript in CML cells. Using array analysis, we determined deregulation of several genes after Bmi-1 silencing. Further, we tested an impact of Bmi-1 siRNA on CML cell growth; however, there was no apparent change after Bmi-1 suppression. Despite Bmi-1 deregulation occurs in CML and its expression is connected to several oncogenic processes it seems to play rather secondary role in CML transformation It has been demonstrated that over-expression of Bmi-1 occurs in variety of cancers, which proposed Bmi-1 as a potential target for therapeutic intervention. In this study, we investigated the role of Bmi-1 in chronic myeloid leukemia (CML). Using qRT-PCR, we demonstrated significantly increased level of Bmi-1 transcript in CML cells. Using array analysis, we determined deregulation of several genes after Bmi-1 silencing. Further, we tested an impact of Bmi-1 siRNA on CML cell growth; however, there was no apparent change after Bmi-1 suppression. Despite Bmi-1 deregulation occurs in CML and its expression is connected to several oncogenic processes it seems to play rather secondary role in CML transformation (en)
Title	Bmi-1 over-expression plays a secondary role in chronic myeloid leukemia transformation Bmi-1 over-expression plays a secondary role in chronic myeloid leukemia transformation (en) Zvýšená exprese Bmi-1 má sekundárním úlohu u chronické myeloidní leukemie (cs)
skos:prefLabel	Bmi-1 over-expression plays a secondary role in chronic myeloid leukemia transformation Bmi-1 over-expression plays a secondary role in chronic myeloid leukemia transformation (en) Zvýšená exprese Bmi-1 má sekundárním úlohu u chronické myeloidní leukemie (cs)
skos:notation	RIV/00023736:_____/07:00007112!RIV07-MZ0-00023736
http://linked.open.../vavai/riv/strany	793;801
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR7989)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Brdička, Radim Dostálová Merkerová, Michaela Vašíková, Alžběta Votavová, Hana Klamová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	412066
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/07:00007112
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CML; proliferation; siRNA; Bmi-1; expression arrays (en)
http://linked.open.../riv/klicoveSlovo	CML Bmi-1 expression arrays siRNA proliferation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E42261416E45]
http://linked.open...i/riv/nazevZdroje	Leukemia and Lymphoma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Targeted gene silencing using siRNAs in primary cell cultures of CML patients and leukemic cell lines (K562, MOLM-7, KU-812)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	48
http://linked.open...iv/tvurceVysledku	Klamová, Hana Brdička, Radim Merkerová, Michaela Bruchová, Hana Kráčmarová, Alžběta
issn	1042-8194
number of pages	9 (xsd:int)

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