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rdf:type
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Description
| - V předchozích publikacích jsme prokázali silnou up-regulaci genu PCNA u chronické myeloidní leukemie (CML). Kvůli studiu role PCNA v patogenezi CML jsme tlumili expresi PCNA pomocí siRNA a následně prováděli čipové experimenty Inhibice PCNA vedla k deregulaci několika genů spojených s buněčným cyklem, apoptózou a transformací. Protože však PCNA ovlivňuje proliferaci leukemických, ale i přirozeně proliferujících buněk, zdá se, že PCNA hraje sekundární roli vzhledem k proliferační aktivitě leukemických buněk (cs)
- Previously, we demonstrated strong PCNA up-regulation in chronic myelogenous leukemia (CML) patients. To further study its role in CML pathogenesis, we performed silencing of PCNA expression followed by array experiments. PCNA inhibition led to deregulation of several genes connected to cell cycle, apoptosis, and transformation. However, as PCNA affects cell growth in naturally proliferating cells as well as in cancerous cells, it seems to act a secondary role relating to proliferation activity of leukemic cells
- Previously, we demonstrated strong PCNA up-regulation in chronic myelogenous leukemia (CML) patients. To further study its role in CML pathogenesis, we performed silencing of PCNA expression followed by array experiments. PCNA inhibition led to deregulation of several genes connected to cell cycle, apoptosis, and transformation. However, as PCNA affects cell growth in naturally proliferating cells as well as in cancerous cells, it seems to act a secondary role relating to proliferation activity of leukemic cells (en)
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Title
| - Expression analysis of PCNA gene in chronic myelogenous leukemia : combined application of siRNA silencing and expression arrays
- Expresní analýza genu PCNA u chronické myeloidní leukemie - kombinované využití siRNA techniky a expresních čipů (cs)
- Expression analysis of PCNA gene in chronic myelogenous leukemia : combined application of siRNA silencing and expression arrays (en)
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skos:prefLabel
| - Expression analysis of PCNA gene in chronic myelogenous leukemia : combined application of siRNA silencing and expression arrays
- Expresní analýza genu PCNA u chronické myeloidní leukemie - kombinované využití siRNA techniky a expresních čipů (cs)
- Expression analysis of PCNA gene in chronic myelogenous leukemia : combined application of siRNA silencing and expression arrays (en)
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skos:notation
| - RIV/00023736:_____/07:00007109!RIV08-MZ0-00023736
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00023736:_____/07:00007109
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cell cycle; CML; electroporation; nucleofection; PCNA; proliferation; siRNA (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brdička, Radim
- Merkerová, Michaela
- Bruchová, Hana
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issn
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number of pages
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