About: UBF expression and ribosomal synthesis in PHA stimulated lymphocytes treated with n-butyric acid.

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About: UBF expression and ribosomal synthesis in PHA stimulated lymphocytes treated with n-butyric acid. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In cells entering the growth-division cycle an increase of cellular content of nucleolar protein UBF parallels the increasing amount of DNA generated by replication. However, within 48 hours following the mitogenic signal, the synthesis of rRNA as well as synthesis of the UBF enhancer is independent of the amount of rDNA copies. Another regulatory mechanism, more likely a process comprising the early phosphorylation of UBF, upregulates the synthesis of rRNA. In cells entering the growth-division cycle an increase of cellular content of nucleolar protein UBF parallels the increasing amount of DNA generated by replication. However, within 48 hours following the mitogenic signal, the synthesis of rRNA as well as synthesis of the UBF enhancer is independent of the amount of rDNA copies. Another regulatory mechanism, more likely a process comprising the early phosphorylation of UBF, upregulates the synthesis of rRNA. (en) Při vstupu klidových buněk do cyklu růst hladiny nukleolárního proteinu UBF kopíruje replikaci DNA avšak není na ní, v prvních 48 hodinách po indukci mitogenního signálu, přímo závislý. Růst rychlosti syntézy ribozomální RNA je tedy podporován jinak nežzmnožováním kopií rDNA. Pravděpodobný mechanizmus zahrnuje časnou aktivační fosforylaci enhanceru UBF. (cs)
Title	UBF expression and ribosomal synthesis in PHA stimulated lymphocytes treated with n-butyric acid. Exprese proteinu UBF a ribosomální syntéza v PHA stimulovaných lymfocytech za působení činidla n-butyric acid. (cs) UBF expression and ribosomal synthesis in PHA stimulated lymphocytes treated with n-butyric acid. (en)
skos:prefLabel	UBF expression and ribosomal synthesis in PHA stimulated lymphocytes treated with n-butyric acid. Exprese proteinu UBF a ribosomální syntéza v PHA stimulovaných lymfocytech za působení činidla n-butyric acid. (cs) UBF expression and ribosomal synthesis in PHA stimulated lymphocytes treated with n-butyric acid. (en)
skos:notation	RIV/00023736:_____/04:I0000103!RIV/2005/MZ0/L33005/N
http://linked.open.../vavai/riv/strany	S183
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR7998), Z(MZ00237360001)
http://linked.open...iv/cisloPeriodika	S2
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Otevřelová, Petra Kalousek, Ivan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	591138
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/04:I0000103
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ribosomal gene;nucleolus;rRNA;UBF phosphorylation;RNA polymerase I;blastic transformation;butyrate;antiproliferative;T-lymphocyte (en)
http://linked.open.../riv/klicoveSlovo	RNA polymerase I butyrate UBF phosphorylation nucleolus antiproliferative T-lymphocyte ribosomal gene rRNA blastic transformation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A461AB7A3FAC]
http://linked.open...i/riv/nazevZdroje	Hematology Journal
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Induction of processes blocking the proliferation of leukemic cells by inhibition of transcription of ribosomal genes.
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Otevřelová, Petra Kalousek, Ivan
http://linked.open...n/vavai/riv/zamer	Pathophysiology,diagnosis, and treatment of blood malignancies and blood coagulation disorders
issn	1466-4860
number of pages	1 (xsd:int)

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