About: Interferon-alpha suppresses proliferation of chronic myelogenous leukemia cells K562 by extending cell cycle S-phase without inducing apoptosis.

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About: Interferon-alpha suppresses proliferation of chronic myelogenous leukemia cells K562 by extending cell cycle S-phase without inducing apoptosis. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The effect of interferon-alpha (IFN-?) on the growth, cell cycle, proliferation, apoptotic parameters, adhesive properties and proteome of chronic myelogenous leukemia K562 cells was examined. IFN-? markedly increased the level of ubiquitine cross-reactive protein and the degradation through ubiquitine-proteasome way may thus play a role in IFN-? antiproliferative effects. The effect of interferon-alpha (IFN-?) on the growth, cell cycle, proliferation, apoptotic parameters, adhesive properties and proteome of chronic myelogenous leukemia K562 cells was examined. IFN-? markedly increased the level of ubiquitine cross-reactive protein and the degradation through ubiquitine-proteasome way may thus play a role in IFN-? antiproliferative effects. (en) Byl zkoumán vliv interferonu-alfa (IFN-?) na růst, buněčný cyklus, proliferaci, apoptotické parametry, adhesivní vlastnosti a proteom buněk chronické myeloidní leukémie K562. IFN-? značně zvýšil hladinu proteinu reagujícího s ubikvitinem a právě degradace ubikvitin-proteasomovou cestou by mohla hrát úlohu v antiproliferačním účinku IFN-?. (cs)
Title	Interferon-alpha suppresses proliferation of chronic myelogenous leukemia cells K562 by extending cell cycle S-phase without inducing apoptosis. Interferon-alpha suppresses proliferation of chronic myelogenous leukemia cells K562 by extending cell cycle S-phase without inducing apoptosis. (en) Interferon-alfa potlačuje proliferaci buněk K562 u chronické myeloidní leukémie prodloužením S-fáze buněčného cyklu, aniž by došlo k indukci apoptózy. (cs)
skos:prefLabel	Interferon-alpha suppresses proliferation of chronic myelogenous leukemia cells K562 by extending cell cycle S-phase without inducing apoptosis. Interferon-alpha suppresses proliferation of chronic myelogenous leukemia cells K562 by extending cell cycle S-phase without inducing apoptosis. (en) Interferon-alfa potlačuje proliferaci buněk K562 u chronické myeloidní leukémie prodloužením S-fáze buněčného cyklu, aniž by došlo k indukci apoptózy. (cs)
skos:notation	RIV/00023736:_____/04:I0000054!RIV/2005/MZ0/L33005/N
http://linked.open.../vavai/riv/strany	262-269
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA303/01/1445), P(NL7681)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Grebeňová, Dana Kuželová, Kateřina Fuchs, Ota Hrkal, Zbyněk Marinov, Iuri
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav hematologie a krevní transfúze
http://linked.open...dnocenehoVysledku	568655
http://linked.open...ai/riv/idVysledku	RIV/00023736:_____/04:I0000054
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	K562;IFN-?;cell-cycle;apoptosis;adhesion;proteomic analysis (en)
http://linked.open.../riv/klicoveSlovo	IFN-? cell-cycle proteomic analysis adhesion apoptosis K562
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B35A73803A2C]
http://linked.open...i/riv/nazevZdroje	Blood Cells, Molecules and Diseases
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of the proteome of malignant cells two-dimensional elektrophoresis and mass spectrometry Exprimental pharmacotherapy of chronic myelogenous leukemia the proteomic approach
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Halada, P. Hrkal, Zbyněk Marinov, Iuri Grebeňová, Dana Kuželová, Kateřina Fuchs, Ota Havlíček, V.
issn	1079-9796
number of pages	8 (xsd:int)

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