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rdf:type
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Description
| - Recombinant vaccinia viruses were used for intratumoral delivery and expression of IL12 genes in tumors induced by HPV16 in mice. Intratumoral therapy with a low dose of recombinant virus slowed down the growth of TC1 tumors, but never caused their regression. When local virus treatment was combined with antigen-specific, DNA-vaccination therapy, no synergy between the two treatments was observed. The highest efficacy of intratumoral therapy was observed with TC-1/A9 cell subline, with downregulated MHC class I expression.
- Recombinant vaccinia viruses were used for intratumoral delivery and expression of IL12 genes in tumors induced by HPV16 in mice. Intratumoral therapy with a low dose of recombinant virus slowed down the growth of TC1 tumors, but never caused their regression. When local virus treatment was combined with antigen-specific, DNA-vaccination therapy, no synergy between the two treatments was observed. The highest efficacy of intratumoral therapy was observed with TC-1/A9 cell subline, with downregulated MHC class I expression. (en)
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Title
| - Experimental therapy of HPV16 induced tumors with IL12 expressed by recombinant vaccinia virus in mice.
- Experimental therapy of HPV16 induced tumors with IL12 expressed by recombinant vaccinia virus in mice. (en)
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skos:prefLabel
| - Experimental therapy of HPV16 induced tumors with IL12 expressed by recombinant vaccinia virus in mice.
- Experimental therapy of HPV16 induced tumors with IL12 expressed by recombinant vaccinia virus in mice. (en)
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skos:notation
| - RIV/00023736:_____/03:00000008!RIV/2004/MZ0/L33004/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(NC7552), Z(MZ00237360001)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00023736:_____/03:00000008
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - vaccinia virus; IL-12; papillomavirus; tumor (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - International Journal of Molecular Medicine
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
| |
http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Šmahel, Michal
- Hainz, Petr
- Kryštofová, Jitka
- Kutinová, Luďa
- Němečková, Šárka
- Šroller, V.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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