About: Impact of splice-site mutations of the human MDR1 cDNA on its stability and expression following retroviral gene transfer.     Goto   Sponge   NotDistinct   Permalink

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Description
  • Aberrant splicing of huMDR1 is a complication for its potential use in gene therapy. We therefore prepared several variants of huMDR1 cDNA by site-directed mutagenesis to eliminate aberrant splicing in target cells. Based on functional tests a variant with better properties than wild type cDNA was found.
  • Aberrant splicing of huMDR1 is a complication for its potential use in gene therapy. We therefore prepared several variants of huMDR1 cDNA by site-directed mutagenesis to eliminate aberrant splicing in target cells. Based on functional tests a variant with better properties than wild type cDNA was found. (en)
Title
  • Impact of splice-site mutations of the human MDR1 cDNA on its stability and expression following retroviral gene transfer.
  • Impact of splice-site mutations of the human MDR1 cDNA on its stability and expression following retroviral gene transfer. (en)
skos:prefLabel
  • Impact of splice-site mutations of the human MDR1 cDNA on its stability and expression following retroviral gene transfer.
  • Impact of splice-site mutations of the human MDR1 cDNA on its stability and expression following retroviral gene transfer. (en)
skos:notation
  • RIV/00023736:_____/03:00000001!RIV/2004/MZ0/L33004/N
http://linked.open.../vavai/riv/strany
  • 1061;1065
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MZ00237360001)
http://linked.open...iv/cisloPeriodika
  • 12
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 609870
http://linked.open...ai/riv/idVysledku
  • RIV/00023736:_____/03:00000001
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • MDR1; retroviral vectors; aberrant splicing; gene therapy (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [B673C47C386C]
http://linked.open...i/riv/nazevZdroje
  • Gene Therapy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...ocetUcastnikuAkce
http://linked.open...nichUcastnikuAkce
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 10
http://linked.open...iv/tvurceVysledku
  • Fuchs, Ota
  • Jelínek, J.
  • Čmejla, Radek
  • Čmejlová, Jana
  • Žáková, Dana
  • Baum, C.
  • Hildinger, M.
http://linked.open...n/vavai/riv/zamer
issn
  • 0969-7128
number of pages
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