About: Nabumetone Induces Less Gastrointestinal Mucosal Changes Than Diclofenac Retard

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the study was to compare the efficacy and the effects on the mucosa of the gastrointestinal tract (GIT) of nabumetone and diclofenac retard in patients with osteoarthritis (OA). An oper multicentre, randomised, comparative ¨, nedoscopy-blind parallel group study included 201 patients with nabumetone and 193 patients with diclofenac retard suffering from moderate to severe OA of the knee or hip joint. Twelve clinical efficacy variables were assesses and a portion of the population underwent gastroduodenoscopy. All patients exhibited significant improvement in pain severity and pain relief ( p < 0.0001, respectively) but there were no differences between the groups for all the efficacy variables. Eleven per cent of patients on nabumetone and19 % on diclofenac experienced GIT side-effects. Sixty-nine patients with nabumetone and 61 with diclofenac underwent gastroduoendoscopy. The differences in the mucosal grade for the oesophagus, stomach and duodenum at baseline were not significant. The aim of the study was to compare the efficacy and the effects on the mucosa of the gastrointestinal tract (GIT) of nabumetone and diclofenac retard in patients with osteoarthritis (OA). An oper multicentre, randomised, comparative ¨, nedoscopy-blind parallel group study included 201 patients with nabumetone and 193 patients with diclofenac retard suffering from moderate to severe OA of the knee or hip joint. Twelve clinical efficacy variables were assesses and a portion of the population underwent gastroduodenoscopy. All patients exhibited significant improvement in pain severity and pain relief ( p < 0.0001, respectively) but there were no differences between the groups for all the efficacy variables. Eleven per cent of patients on nabumetone and19 % on diclofenac experienced GIT side-effects. Sixty-nine patients with nabumetone and 61 with diclofenac underwent gastroduoendoscopy. The differences in the mucosal grade for the oesophagus, stomach and duodenum at baseline were not significant. (en)
Title	Nabumetone Induces Less Gastrointestinal Mucosal Changes Than Diclofenac Retard Nabumetone Induces Less Gastrointestinal Mucosal Changes Than Diclofenac Retard (en)
skos:prefLabel	Nabumetone Induces Less Gastrointestinal Mucosal Changes Than Diclofenac Retard Nabumetone Induces Less Gastrointestinal Mucosal Changes Than Diclofenac Retard (en)
skos:notation	RIV/00023728:_____/99:00000018!RIV/2000/MZ0/L29000
http://linked.open.../vavai/riv/strany	273
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(IZ2911)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2000
http://linked.open...aciTvurceVysledku	Pavelka, Karel Urbanová, Zuzana Bečvář, Radim
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Revmatologický ústav
http://linked.open...dnocenehoVysledku	746854
http://linked.open...ai/riv/idVysledku	RIV/00023728:_____/99:00000018
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	diclofenac, efficacy, endoscopy, Nabumetone, osteoarthritis, safety (en)
http://linked.open.../riv/klicoveSlovo	efficacy osteoarthritis Nabumetone endoscopy - digestive system - surgery - colorectal carcinoma safety diclofenac
http://linked.open...odStatuVydavatele	BE - Belgické království
http://linked.open...ontrolniKodProRIV	[3D713534EAB5]
http://linked.open...i/riv/nazevZdroje	Clinical Rheumatology
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	18 (xsd:int)
http://linked.open...vavai/riv/projekt	Microscopic vascular changes,markers of vaskular injury and immunological abnormalities in bronchoalveolar lavage of patients with progressive systemic sclerosi
http://linked.open...UplatneniVysledku	1999
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Pavelka, Karel Urbanová, Zuzana Bečvář, Radim Vlasáková, V.
issn	0770-3198
number of pages	6 (xsd:int)

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