About: The HLA-Cw*06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population

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About: The HLA-Cw*06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Psoriatic arthritis (PsA) affects approximately 30 % of patients suffering from psoriasis vulgaris (PsV), but the risk factors for its development have not been well elucidated yet. The HLA-Cw06 allele was described as a predisposing factor to PsV. Prolactin is known as an immune response modulator, and its elevated levels present risk for PsV development. It is possible that these factors interact and together emphasize the predisposition to bothdiseases. We tested on an association of HLA-Cw alleles and functional polymorphism -1149 G/T in PRL gene extrapituitary promoter with PsV and PsA in Czech population. We found a statistically significant association between HLA-Cw06 allele and PsV (Pcorrected = 0.0013) that was most prominent in early onset disease subtype (Pcorrected = 0.0013). The association between HLA-Cw06 and PsA was low (Pcorrected = 0.0585) and restricted to PsA patients with early PsV onset (Pcorrected = 0.0195). We found no association of - 1149 G/T PRL gene polymorphism with either PsV or PsA. Psoriatic arthritis (PsA) affects approximately 30 % of patients suffering from psoriasis vulgaris (PsV), but the risk factors for its development have not been well elucidated yet. The HLA-Cw06 allele was described as a predisposing factor to PsV. Prolactin is known as an immune response modulator, and its elevated levels present risk for PsV development. It is possible that these factors interact and together emphasize the predisposition to bothdiseases. We tested on an association of HLA-Cw alleles and functional polymorphism -1149 G/T in PRL gene extrapituitary promoter with PsV and PsA in Czech population. We found a statistically significant association between HLA-Cw06 allele and PsV (Pcorrected = 0.0013) that was most prominent in early onset disease subtype (Pcorrected = 0.0013). The association between HLA-Cw06 and PsA was low (Pcorrected = 0.0585) and restricted to PsA patients with early PsV onset (Pcorrected = 0.0195). We found no association of - 1149 G/T PRL gene polymorphism with either PsV or PsA. (en)
Title	The HLA-Cw06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population The HLA-Cw06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population (en)
skos:prefLabel	The HLA-Cw06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population The HLA-Cw06 allele and -1149 G/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population (en)
skos:notation	RIV/00023728:_____/14:#0003047!RIV14-MZ0-00023728
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(NS10618), S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Fojtíková, Markéta Šedová, Liliana Štolfa, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Revmatologický ústav
http://linked.open...dnocenehoVysledku	77592
http://linked.open...ai/riv/idVysledku	RIV/00023728:_____/14:#0003047
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	psoriasis; psoriatic arthritis; prolactin; gene; HLA; predisposition (en)
http://linked.open.../riv/klicoveSlovo	gene HLA prolactin predisposition psoriasis psoriatic arthritis
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[356BF684FD1E]
http://linked.open...i/riv/nazevZdroje	RHEUMATOLOGY INTERNATIONAL 2013 Volume: 33 Issue: 4 Pages: 913-919
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of the prolactin gene polymorphism and its expression in peripheral mononuclear cells in the autoimmune diseases pathogenesis – systemic lupus erythematosus, inflammatory joint diseases (psoriatic and rheumatoid arthritis) and psoriasis vulgaris
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Arenberger, P. Černá, M. Fojtíková, Markéta Šedová, Liliana Štolfa, Jiří Čejková, P. Cibulová, A. Lippert, J. Zajacová, M.
http://linked.open...ain/vavai/riv/wos	000316971800014
issn	0172-8172
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00296-012-2472-7

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