About: Inhibition of Notch Signaling Prevents Experimental Fibrosis and Induces Regression of Established Fibrosis     Goto   Sponge   NotDistinct   Permalink

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  • The present results demonstrate that pharmacologic as well as genetic inhibition of Notch signaling exerts potent antifibrotic effects in different murine models of SSc. These findings might have direct translational implications because different inhibitors of the gama-secretase complex are available and have yielded promising results in cancer trials.
  • The present results demonstrate that pharmacologic as well as genetic inhibition of Notch signaling exerts potent antifibrotic effects in different murine models of SSc. These findings might have direct translational implications because different inhibitors of the gama-secretase complex are available and have yielded promising results in cancer trials. (en)
Title
  • Inhibition of Notch Signaling Prevents Experimental Fibrosis and Induces Regression of Established Fibrosis
  • Inhibition of Notch Signaling Prevents Experimental Fibrosis and Induces Regression of Established Fibrosis (en)
skos:prefLabel
  • Inhibition of Notch Signaling Prevents Experimental Fibrosis and Induces Regression of Established Fibrosis
  • Inhibition of Notch Signaling Prevents Experimental Fibrosis and Induces Regression of Established Fibrosis (en)
skos:notation
  • RIV/00023728:_____/11:#0001046!RIV12-MZ0-00023728
http://linked.open...avai/riv/aktivita
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  • S, Z(MZ00000023728)
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  • 5
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  • 204845
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  • RIV/00023728:_____/11:#0001046
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • GAMMA-SECRETASE INHIBITOR; SYSTEMIC-SCLEROSIS; DERMAL FIBROSIS; PATHWAY; DISEASE; CANCER; SCLERODERMA; ACTIVATION; MATRIX; SAFETY (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [FEF99FE7FB41]
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  • Arthritis and Rheumatism
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  • 63
http://linked.open...iv/tvurceVysledku
  • Akhmetshina, A.
  • Beyer, C.
  • Dees, C.
  • Distler, J.H.W.
  • Distler, O.
  • Horn, A.
  • Mattson, M. P.
  • Palumbo, K.
  • Reich, N.
  • Schett, G.
  • Sticherling, M.
  • Tomčík, Michal
  • Zerr, P.
  • Zwerina, J.
http://linked.open...ain/vavai/riv/wos
  • 000290609800029
http://linked.open...n/vavai/riv/zamer
issn
  • 0004-3591
number of pages
http://bibframe.org/vocab/doi
  • 10.1002/art.30254
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