About: The transcription factor JunD mediates transforming growth factor beta-induced fibroblast activation and fibrosis in systemic sclerosis     Goto   Sponge   NotDistinct   Permalink

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Description
  • These data demonstrate that JunD is overexpressed in SSc and that JunD is a mediator of the profibrotic effects of TGFβ. Considering that inhibitors of AP-1 signalling have recently been developed and are available for clinical trials in SSc, these findings may have translational implications.
  • These data demonstrate that JunD is overexpressed in SSc and that JunD is a mediator of the profibrotic effects of TGFβ. Considering that inhibitors of AP-1 signalling have recently been developed and are available for clinical trials in SSc, these findings may have translational implications. (en)
Title
  • The transcription factor JunD mediates transforming growth factor beta-induced fibroblast activation and fibrosis in systemic sclerosis
  • The transcription factor JunD mediates transforming growth factor beta-induced fibroblast activation and fibrosis in systemic sclerosis (en)
skos:prefLabel
  • The transcription factor JunD mediates transforming growth factor beta-induced fibroblast activation and fibrosis in systemic sclerosis
  • The transcription factor JunD mediates transforming growth factor beta-induced fibroblast activation and fibrosis in systemic sclerosis (en)
skos:notation
  • RIV/00023728:_____/11:#0001045!RIV12-MZ0-00023728
http://linked.open...avai/riv/aktivita
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  • S, Z(MZ00000023728)
http://linked.open...iv/cisloPeriodika
  • 7
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  • 235761
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  • RIV/00023728:_____/11:#0001045
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • EXTRACELLULAR-MATRIX; DERMAL FIBROSIS; STELLATE CELLS; PROTEIN-1; SCLERODERMA; EXPRESSION; MECHANISMS; INHIBITOR; APOPTOSIS; PROTECTS (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [E4E09FE1D85A]
http://linked.open...i/riv/nazevZdroje
  • Annals of the Rheumatoid Diseases
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http://linked.open...UplatneniVysledku
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  • 70
http://linked.open...iv/tvurceVysledku
  • Akhmetshina, A.
  • Dees, C.
  • Distler, J.H.W.
  • Distler, O.
  • Palumbo, K.
  • Schett, G.
  • Tomčík, Michal
  • Zerr, P.
  • Avouac J, J.
  • Vollath, S.
  • Yaniv, M.
http://linked.open...ain/vavai/riv/wos
  • 000291028800025
http://linked.open...n/vavai/riv/zamer
issn
  • 0003-4967
number of pages
http://bibframe.org/vocab/doi
  • 10.1136/ard.2010.148296
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