About: Inactivation of the Cannabinoid Receptor CB1 Prevents Leukocyte Infiltration and Experimental Fibrosis     Goto   Sponge   NotDistinct   Permalink

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  • We demonstrate that the cannabinoid receptor CB1 is crucial for leukocyte infiltration and secondary fibroblast activation in experimental fibrosis and that inactivation of CB1 exerts potent anti-fibrotic effects. These findings might have direct translational implications because selective antagonists of CB1 that efficiently target CB1 in humans are available.
  • We demonstrate that the cannabinoid receptor CB1 is crucial for leukocyte infiltration and secondary fibroblast activation in experimental fibrosis and that inactivation of CB1 exerts potent anti-fibrotic effects. These findings might have direct translational implications because selective antagonists of CB1 that efficiently target CB1 in humans are available. (en)
Title
  • Inactivation of the Cannabinoid Receptor CB1 Prevents Leukocyte Infiltration and Experimental Fibrosis
  • Inactivation of the Cannabinoid Receptor CB1 Prevents Leukocyte Infiltration and Experimental Fibrosis (en)
skos:prefLabel
  • Inactivation of the Cannabinoid Receptor CB1 Prevents Leukocyte Infiltration and Experimental Fibrosis
  • Inactivation of the Cannabinoid Receptor CB1 Prevents Leukocyte Infiltration and Experimental Fibrosis (en)
skos:notation
  • RIV/00023728:_____/10:#0000072!RIV11-MZ0-00023728
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 11
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  • 263313
http://linked.open...ai/riv/idVysledku
  • RIV/00023728:_____/10:#0000072
http://linked.open...riv/jazykVysledku
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  • monocyte chemoattractant protein-1; experimental dermal fibrosis; systemic-sclerosis; bone mass; extracellular-matrix; tissue; pathogenesis; fibroblasts; scleroderma; antagonists (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [6BA23DA07069]
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  • ARTHRITIS AND RHEUMATISM
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  • 62
http://linked.open...iv/tvurceVysledku
  • Akhmetshina, Alfiya
  • Dees, Clara
  • Distler, Oliver
  • Horn, Angelika
  • Palumbo, Katrin
  • Tomčík, Michal
  • Zerr, Pawel
  • Zwerina, Jochen
  • Distler, Joerg H. W.
  • Reich, Nicole
  • Schett, Georg
  • Engel, Matthias
  • Marquart, Sieglinde
http://linked.open...ain/vavai/riv/wos
  • 283776400038
issn
  • 0004-3591
number of pages
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