About: CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation

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About: CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.biomedcentral.com/1471-2172/15/4
Description	Monocytes represent a heterogeneuos population of cells subdivided according to the expression level of membrane antigens. A pro-inflammatory (intermediate/nonclassical) subpopulation of monocytes is defined by expression of CD16. CD163 seems to be characteristically preferentially expressed by immunosuppressive monocytes.The aim of our study was to avaluete the distribution of monocyte subpopulations in 71 patients with kidney allograft transplantation. The phenotype was evaluated by flow cytometry in defined time points. The proportions of peripheral CD14+CD16+ monocytes were downregulated immediately after the kidney transplantation and basiliximab treatment partially attenuated this trend. The transient downregulation of the CD14+CD16+ subpopulation was adjust to basal values in two months. The proportions of CD14+Cd163+ monocytes were transietlyupregulated early after the kidney transplantation and remained higher during the first month in most patients. In ATG treated patients, the expansion of CD14+Cd163+ monocytes was delayd but their upregulation lasted longer. Monocytes represent a heterogeneuos population of cells subdivided according to the expression level of membrane antigens. A pro-inflammatory (intermediate/nonclassical) subpopulation of monocytes is defined by expression of CD16. CD163 seems to be characteristically preferentially expressed by immunosuppressive monocytes.The aim of our study was to avaluete the distribution of monocyte subpopulations in 71 patients with kidney allograft transplantation. The phenotype was evaluated by flow cytometry in defined time points. The proportions of peripheral CD14+CD16+ monocytes were downregulated immediately after the kidney transplantation and basiliximab treatment partially attenuated this trend. The transient downregulation of the CD14+CD16+ subpopulation was adjust to basal values in two months. The proportions of CD14+Cd163+ monocytes were transietlyupregulated early after the kidney transplantation and remained higher during the first month in most patients. In ATG treated patients, the expansion of CD14+Cd163+ monocytes was delayd but their upregulation lasted longer. (en)
Title	CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation (en)
skos:prefLabel	CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation (en)
skos:notation	RIV/00023001:_____/14:00058834!RIV15-GA0-00023001
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP301/11/1568)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Brabcová, Eva Stříž, Ilja Viklický, Ondřej Lánská, Věra Sekerková, Alena Slatinská, Janka Kryštůfková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	6356
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/14:00058834
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CD14+Cd16+, CD14+CD163+, Kidney, Monocytes, Subpopulations, Transplantation (en)
http://linked.open.../riv/klicoveSlovo	Monocytes CD14+CD163+ CD14+Cd16+ Subpopulations Kidney Transplantation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[487B7DC887E3]
http://linked.open...i/riv/nazevZdroje	BMC IMMUNOLOGY
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Cellular aspects of transplantation tolerance
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Lánská, Věra Viklický, Ondřej Sekerková, Alena Brabcová, Eva Stříž, Ilja Slatinská, Janka Krepsová, Eva
http://linked.open...ain/vavai/riv/wos	000332972400001
issn	1471-2172
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/1471-2172-15-4

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