About: Implantation of left ventricular assist device complicated by undiagnosed thrombophilia

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461681/
Description	A patient with dilated cardiomyopathy and no history of thromboembolic events received a surgically implanted axial-flow left ventricular assist device. After implantation, transesophageal echocardiography revealed a giant thrombus on the lateral and anterior aspects of the left ventricle. The inflow cannula inserted through the apex of the left ventricle was not obstructed, and the device generated satisfactory blood flow. Laboratory screening for thrombophilia showed protein S deficiency, heterozygous factor V Leiden mutation, and heterozygous MTHFR C667T mutation. During the entire duration of circulatory support no significant suction events were detected, and the patient was listed for heart transplantation. Ventricular assist device implantation can unmask previously undiagnosed thrombophilia; therefore, it should be necessary to identify thrombophilic patients before cardiac support implantation. (Tex Heart Inst J 2012;39(5):615-7) A patient with dilated cardiomyopathy and no history of thromboembolic events received a surgically implanted axial-flow left ventricular assist device. After implantation, transesophageal echocardiography revealed a giant thrombus on the lateral and anterior aspects of the left ventricle. The inflow cannula inserted through the apex of the left ventricle was not obstructed, and the device generated satisfactory blood flow. Laboratory screening for thrombophilia showed protein S deficiency, heterozygous factor V Leiden mutation, and heterozygous MTHFR C667T mutation. During the entire duration of circulatory support no significant suction events were detected, and the patient was listed for heart transplantation. Ventricular assist device implantation can unmask previously undiagnosed thrombophilia; therefore, it should be necessary to identify thrombophilic patients before cardiac support implantation. (Tex Heart Inst J 2012;39(5):615-7) (en)
Title	Implantation of left ventricular assist device complicated by undiagnosed thrombophilia Implantation of left ventricular assist device complicated by undiagnosed thrombophilia (en)
skos:prefLabel	Implantation of left ventricular assist device complicated by undiagnosed thrombophilia Implantation of left ventricular assist device complicated by undiagnosed thrombophilia (en)
skos:notation	RIV/00023001:_____/12:00055978!RIV13-MZ0-00023001
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Malý, Jiří Szárszoi, Ondrej Skalský, Ivo Netuka, Ivan Pirk, Jan Urban, Marian Říha, Hynek Turek, Daniel Malušková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	140768
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/12:00055978
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	thrombus/etiology/prevention & control; thrombophilia/genetics; postoperative complications; perioperative care; left ventricular assist device; factor V Leiden; factor V/genetics; blood coagulation disorders/complications; Anticoagulants/therapeutic use (en)
http://linked.open.../riv/klicoveSlovo	left ventricular assist device Anticoagulants/therapeutic use blood coagulation disorders/complications factor V Leiden factor V/genetics thrombophilia/genetics thrombus/etiology/prevention & control perioperative care postoperative complications
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E1F69F4DCE19]
http://linked.open...i/riv/nazevZdroje	Texas Heart Institute Journal
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	39
http://linked.open...iv/tvurceVysledku	Malý, Jiří Netuka, Ivan Pirk, Jan Skalský, Ivo Szárszoi, Ondrej Urban, Marian Říha, Hynek Turek, Daniel Malušková, Jana
http://linked.open...ain/vavai/riv/wos	000309796700004
issn	0730-2347
number of pages	3 (xsd:int)

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