About: Two forms of iron as an intrinsic contrast agent in the basal ganglia of PKAN patients

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About: Two forms of iron as an intrinsic contrast agent in the basal ganglia of PKAN patients Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1002/cmmi.1482/abstract;jsessionid=B9FFDDFAC5297715016370CB37AE33B2.d03t02
Description	Iron deposits in the human brain can be considered as intrinsic contrast agents for magnetic resonance imaging and are used as markers of neurodegeneration accompanied by brain-iron accumulation. We studied one of them panthotenate-kinase associated neurodegeneration (PKAN) by using relaxometry at 1.5, 3.0 and 7 T in a group of six patients; we also measured a group of five volunteers for comparison. Based on the magnetic field dependency of antiferromagnetic ferritin and maghemite iron oxide nanoparticle relaxivities, we derived a two-component model for the description of iron deposits in the globus pallidus of PKAN patients. According to this model, we estimated the iron content in PKAN patients as 391 mu g/ml of antiferromagnetic iron (ferritin) and 1.1 mu g/ml of ferrimagnetic iron, compared with 178 mu g/ml of iron in ferritin found in controls. This two-component model explains the nonlinear shape of the relaxometric curves in in vivo measurements of the relaxation rates of PKAN patients and is supported by histological findings in the original reports on PKAN patients. Iron deposits in the human brain can be considered as intrinsic contrast agents for magnetic resonance imaging and are used as markers of neurodegeneration accompanied by brain-iron accumulation. We studied one of them panthotenate-kinase associated neurodegeneration (PKAN) by using relaxometry at 1.5, 3.0 and 7 T in a group of six patients; we also measured a group of five volunteers for comparison. Based on the magnetic field dependency of antiferromagnetic ferritin and maghemite iron oxide nanoparticle relaxivities, we derived a two-component model for the description of iron deposits in the globus pallidus of PKAN patients. According to this model, we estimated the iron content in PKAN patients as 391 mu g/ml of antiferromagnetic iron (ferritin) and 1.1 mu g/ml of ferrimagnetic iron, compared with 178 mu g/ml of iron in ferritin found in controls. This two-component model explains the nonlinear shape of the relaxometric curves in in vivo measurements of the relaxation rates of PKAN patients and is supported by histological findings in the original reports on PKAN patients. (en)
Title	Two forms of iron as an intrinsic contrast agent in the basal ganglia of PKAN patients Two forms of iron as an intrinsic contrast agent in the basal ganglia of PKAN patients (en)
skos:prefLabel	Two forms of iron as an intrinsic contrast agent in the basal ganglia of PKAN patients Two forms of iron as an intrinsic contrast agent in the basal ganglia of PKAN patients (en)
skos:notation	RIV/00023001:_____/12:00055865!RIV13-MZ0-00023001
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(NS10523)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Hájek, Milan Herynek, Vít Dezortová, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	175461
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/12:00055865
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SPIO; ferritin; iron deposits; PKAN; basal ganglia; MR relaxometry (en)
http://linked.open.../riv/klicoveSlovo	PKAN iron deposits ferritin SPIO MR relaxometry basal ganglia
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D47D2B5DE3E9]
http://linked.open...i/riv/nazevZdroje	Contrast Media and Molecular Imaging
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Long-term evolution of morphology and metabolism in the brain after liver transplantation
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Hájek, Milan Dezortová, Monika Herynek, Vít Kronerwetter, Claudia Krssak, Martin Trattnig, Siegfried
http://linked.open...ain/vavai/riv/wos	000308940900005
issn	1555-4309
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/cmmi.1482

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