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  • Noninvasive cellular imaging allows the real-time tracking of grafted cells as well as the monitoring of their migration. In this review, we will focus on cell tracking using MRI, since MRI is noninvasive, clinically transferable, and displays good resolution, ranging from 50 μm in animal experiments up to 300 μm using whole body clinical scanners. In addition to information about grafted cells, MRI provides information about the surrounding tissue (i.e., lesion size, edema, inflammation), which may negatively affect graft survival or the functional recovery of the tissue. Transplanted cells are labeled with MR contrast agents in vitro prior to transplantation in order to visualize them in the host tissue. The chapter will focus on the use of superparamagnetic iron oxide nanoparticles (SPIO), because they have strong effects on T2 relaxation yet do not affect cell viability, and will provide an overview of different modifications of SPIO and their use in MR tracking in living organisms.
  • Noninvasive cellular imaging allows the real-time tracking of grafted cells as well as the monitoring of their migration. In this review, we will focus on cell tracking using MRI, since MRI is noninvasive, clinically transferable, and displays good resolution, ranging from 50 μm in animal experiments up to 300 μm using whole body clinical scanners. In addition to information about grafted cells, MRI provides information about the surrounding tissue (i.e., lesion size, edema, inflammation), which may negatively affect graft survival or the functional recovery of the tissue. Transplanted cells are labeled with MR contrast agents in vitro prior to transplantation in order to visualize them in the host tissue. The chapter will focus on the use of superparamagnetic iron oxide nanoparticles (SPIO), because they have strong effects on T2 relaxation yet do not affect cell viability, and will provide an overview of different modifications of SPIO and their use in MR tracking in living organisms. (en)
Title
  • Magnetic resonance imaging of stem cell migration
  • Magnetic resonance imaging of stem cell migration (en)
skos:prefLabel
  • Magnetic resonance imaging of stem cell migration
  • Magnetic resonance imaging of stem cell migration (en)
skos:notation
  • RIV/00023001:_____/11:00002741!RIV12-AV0-00023001
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0538), P(GA203/09/1242), P(KAN201110651)
http://linked.open...iv/cisloPeriodika
  • part 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 210233
http://linked.open...ai/riv/idVysledku
  • RIV/00023001:_____/11:00002741
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • SPIO; MRI; stem cells (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [395C1EAEE7DD]
http://linked.open...i/riv/nazevZdroje
  • Methods in Molecular Biology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 750
http://linked.open...iv/tvurceVysledku
  • Syková, Eva
  • Jendelová, Pavla
  • Herynek, Vít
issn
  • 1064-3745
number of pages
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