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  • Introduction Colorectal cancer (CRC) is one of the most serious health problems worldwide and thus it is important to assess health and economic impacts of preventative CRC screening strategies. Methods For this reason, a theoretical model based on Markov chains is proposed to compare these strategies: fecal occult blood test, capsule endoscopy, once-life and twice-life colonoscopy, and no screening. The model predicts the health state of a population of individuals aged from 50 to 75 years. Results The numerical results show that the optimal timing for a once-lifetime colonoscopy screening method is before the age of 50 and that the twice-lifetime colonoscopy is the best screening strategy with respect to CRC incidence. In contrast, it is the most expensive one if the CRC treatment costs are not included. The model predicts that there is a minimal CRC incidence in the population when the second colonoscopy is appropriately timed. By using specific data, this age was found to be 59 years.
  • Introduction Colorectal cancer (CRC) is one of the most serious health problems worldwide and thus it is important to assess health and economic impacts of preventative CRC screening strategies. Methods For this reason, a theoretical model based on Markov chains is proposed to compare these strategies: fecal occult blood test, capsule endoscopy, once-life and twice-life colonoscopy, and no screening. The model predicts the health state of a population of individuals aged from 50 to 75 years. Results The numerical results show that the optimal timing for a once-lifetime colonoscopy screening method is before the age of 50 and that the twice-lifetime colonoscopy is the best screening strategy with respect to CRC incidence. In contrast, it is the most expensive one if the CRC treatment costs are not included. The model predicts that there is a minimal CRC incidence in the population when the second colonoscopy is appropriately timed. By using specific data, this age was found to be 59 years. (en)
Title
  • Comparison of various strategies for colorectal cancer screening tests
  • Comparison of various strategies for colorectal cancer screening tests (en)
skos:prefLabel
  • Comparison of various strategies for colorectal cancer screening tests
  • Comparison of various strategies for colorectal cancer screening tests (en)
skos:notation
  • RIV/00023001:_____/11:00002714!RIV12-MZ0-00023001
http://linked.open...avai/riv/aktivita
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http://linked.open...dnocenehoVysledku
  • 191310
http://linked.open...ai/riv/idVysledku
  • RIV/00023001:_____/11:00002714
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • capsule endoscopy; colonoscopy; colorectal cancer; screening; fecal occult blood test; Markov model (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [3DBC0101CB57]
http://linked.open...i/riv/nazevZdroje
  • European journal of gastroenterology and hepatology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 23
http://linked.open...iv/tvurceVysledku
  • Bednarik, Michal
  • Cervenka, Milan
  • Wohl, Pavel
  • Wohl, Petr
  • Špičák, Julius
http://linked.open...ain/vavai/riv/wos
  • 000296752100010
issn
  • 0954-691X
number of pages
http://bibframe.org/vocab/doi
  • 10.1097/MEG.0b013e3283491438
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