About: MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients

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About: MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Among several non-invasive methods of liver fat analysis, the most important role is played by MR imaging and spectroscopy (MRS). This study describes the 1H MRS at 3T measurement of liver fat volume fraction fat in a group of liver transplant patients, an at-risk group for the development of de novo steatosis. Linear and non-linear regression models were used to describe the relationship between fat and His. Strong correlation was found for both models with r =0.83-0.94 (p<0.001); a higher r was found for non-linear regression in all tested groups. Areas under receiver operation curves were calculated for cut points His >= 5% and >33% and were found in the range of 0.77-0.86. Fibrosis influences the calculation of fat and different slopes were obtained for fibrosis stage F0-F1 and F2-F3, respectively. Significant correlation was found between the results of histology and 1H MRS measurement of liver fat content. The method is suitable for non-invasive repetitive examination of liver fat in liver-transplants patients between protocol biopsies and for the screening of steatosis in other liver diseases. Among several non-invasive methods of liver fat analysis, the most important role is played by MR imaging and spectroscopy (MRS). This study describes the 1H MRS at 3T measurement of liver fat volume fraction fat in a group of liver transplant patients, an at-risk group for the development of de novo steatosis. Linear and non-linear regression models were used to describe the relationship between fat and His. Strong correlation was found for both models with r =0.83-0.94 (p<0.001); a higher r was found for non-linear regression in all tested groups. Areas under receiver operation curves were calculated for cut points His >= 5% and >33% and were found in the range of 0.77-0.86. Fibrosis influences the calculation of fat and different slopes were obtained for fibrosis stage F0-F1 and F2-F3, respectively. Significant correlation was found between the results of histology and 1H MRS measurement of liver fat content. The method is suitable for non-invasive repetitive examination of liver fat in liver-transplants patients between protocol biopsies and for the screening of steatosis in other liver diseases. (en)
Title	MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients (en)
skos:prefLabel	MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients (en)
skos:notation	RIV/00023001:_____/11:00002472!RIV12-MZ0-00023001
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NS9707), P(NT11238), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hájek, Milan Trunečka, Pavel Voska, Luděk Dezortová, Monika Wagnerová, Dita Hejlová, Irena Škoch, Antonín
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	214130
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/11:00002472
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	biopsy; lipids; liver steatosis; liver transplantation; magnetic resonance spectroscopy (en)
http://linked.open.../riv/klicoveSlovo	liver steatosis magnetic resonance spectroscopy liver transplantation lipids biopsy
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[71392683B5F9]
http://linked.open...i/riv/nazevZdroje	Magnetic resonance materials in physics, biology and medicine
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Prevalence, causes, progress, and significance of liver allograf steatosis Diet Intervention in Subjects with Type 2 Diabetes: Effect of Meal Frequency and Composition on Glucose Metabolism and Symptoms of Metabolic Syndrome
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Trunečka, Pavel Hájek, Milan Voska, Luděk Dezortová, Monika Hejlová, Irena Wagnerová, Dita Škoch, Antonín
http://linked.open...ain/vavai/riv/wos	000295177400005
http://linked.open...n/vavai/riv/zamer	Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů
issn	0968-5243
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s10334-011-0264-9

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