About: In vivo 31P MR spectroscopy of human kidney grafts using the 2D-chemical shift imaging method

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About: In vivo 31P MR spectroscopy of human kidney grafts using the 2D-chemical shift imaging method Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this work was to evaluate the possibility to use in vivo (31)P magnetic resonance spectroscopy (MRS) for the diagnosis of kidney graft dysfunction after transplantation. We examined 68 kidney grafted patients using a 1.5 T MR scanner. (31)P MRS was performed using the 2D-chemical shift imaging method. The patients were divided into 4 groups: acute rejection episode; acute tubular necrosis; late graft dysfunction; or good renal function. We measured the signal intensities of phosphomonoesters (PME), inorganic phosphate (Pi), phosphodiesters (PDE), and α-, β-, γ-adenosine triphosphate (ATP; with contributions of α- and β-adenosine diphosphate) and their ratios. Patients with an acute rejection episodes showed a significantly elevated PME/β-ATP and PDE/β-ATP, PME/Pi, and PDE/Pi signal ratios compared with the control group. The group with acute tubular necrosis had decreased ratios. Patients with late graft dysfunction revealed only an insignificant decrease in PME/Pi and PDE/Pi ratios. We concluded that (31)P MRS was capable of distinguishing the two main causes of graft dysfunction early after transplantation. The aim of this work was to evaluate the possibility to use in vivo (31)P magnetic resonance spectroscopy (MRS) for the diagnosis of kidney graft dysfunction after transplantation. We examined 68 kidney grafted patients using a 1.5 T MR scanner. (31)P MRS was performed using the 2D-chemical shift imaging method. The patients were divided into 4 groups: acute rejection episode; acute tubular necrosis; late graft dysfunction; or good renal function. We measured the signal intensities of phosphomonoesters (PME), inorganic phosphate (Pi), phosphodiesters (PDE), and α-, β-, γ-adenosine triphosphate (ATP; with contributions of α- and β-adenosine diphosphate) and their ratios. Patients with an acute rejection episodes showed a significantly elevated PME/β-ATP and PDE/β-ATP, PME/Pi, and PDE/Pi signal ratios compared with the control group. The group with acute tubular necrosis had decreased ratios. Patients with late graft dysfunction revealed only an insignificant decrease in PME/Pi and PDE/Pi ratios. We concluded that (31)P MRS was capable of distinguishing the two main causes of graft dysfunction early after transplantation. (en)
Title	In vivo 31P MR spectroscopy of human kidney grafts using the 2D-chemical shift imaging method In vivo 31P MR spectroscopy of human kidney grafts using the 2D-chemical shift imaging method (en)
skos:prefLabel	In vivo 31P MR spectroscopy of human kidney grafts using the 2D-chemical shift imaging method In vivo 31P MR spectroscopy of human kidney grafts using the 2D-chemical shift imaging method (en)
skos:notation	RIV/00023001:_____/11:00002463!RIV12-MZ0-00023001
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NT11275), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hájek, Milan Viklický, Ondřej Herynek, Vít Vyhnanovská, Pavlína Dezortová, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	204059
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/11:00002463
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	31 P MRS; 2D-Chemical Shift Imaging; human kidney (en)
http://linked.open.../riv/klicoveSlovo	2D-Chemical Shift Imaging 31 P MRS human kidney
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[878C7B0656B4]
http://linked.open...i/riv/nazevZdroje	Transplantation Proceedings
http://linked.open...in/vavai/riv/obor	FS
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Phosphorus MR spectroscopy in vivo at 3T
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Viklický, Ondřej Hájek, Milan Dezortová, Monika Herynek, Vít Táborský, Petr Vyhnanovská, Pavlína
http://linked.open...ain/vavai/riv/wos	000292279800033
http://linked.open...n/vavai/riv/zamer	Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů
issn	0041-1345
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.transproceed.2010.11.027

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