About: Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata

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About: Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A novel homologue of insect defensin designated lucifensin (Lucilia defensin) was purified from the extracts of various tissues (gut, salivary glands, fat body, haemolymph) of green bottle fly (Lucilia sericata) larvae and from their excretions/secretions. The primary sequence of this peptide of 40 residues and three intramolecular disulfide bridges was determined by ESI-QTOF mass spectrometry and Edman degradation and is very similar to that of sapecin and other dipteran defensins. We assume that lucifensin is the key antimicrobial component that protects the maggots when they are exposed to the highly infectious environment of a wound during the medicinal process known as maggot therapy. We also believe that lucifensin is that long-sought larger molecular weight antimicrobial factor of the Lucilia sericata excretions/secretions believed to be effective against pathogenic elements of the wound microbial flora. A novel homologue of insect defensin designated lucifensin (Lucilia defensin) was purified from the extracts of various tissues (gut, salivary glands, fat body, haemolymph) of green bottle fly (Lucilia sericata) larvae and from their excretions/secretions. The primary sequence of this peptide of 40 residues and three intramolecular disulfide bridges was determined by ESI-QTOF mass spectrometry and Edman degradation and is very similar to that of sapecin and other dipteran defensins. We assume that lucifensin is the key antimicrobial component that protects the maggots when they are exposed to the highly infectious environment of a wound during the medicinal process known as maggot therapy. We also believe that lucifensin is that long-sought larger molecular weight antimicrobial factor of the Lucilia sericata excretions/secretions believed to be effective against pathogenic elements of the wound microbial flora. (en)
Title	Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata (en)
skos:prefLabel	Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata (en)
skos:notation	RIV/00023001:_____/10:00002383!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GA203/08/0536), V, Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Bém, Robert
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	269011
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002383
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antimicrobial peptide; insect defensin; maggot therapy; Lucilia sericata (en)
http://linked.open.../riv/klicoveSlovo	insect defensin maggot therapy antimicrobial peptide Lucilia sericata
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[7898B601A3EC]
http://linked.open...i/riv/nazevZdroje	Cellular and molecular life sciences
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Antimicrobial peptides from insects for possible therapeutic applications
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	67
http://linked.open...iv/tvurceVysledku	Bém, Robert Voburka, Z. Cerovsky, V. Fucik, V. Monincova, L. Zdarek, J.
http://linked.open...ain/vavai/riv/wos	000273351900010
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	1420-682X
number of pages	12 (xsd:int)

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