About: Calreticulin is a B cell molecular target in some gastrointestinal malignancies

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	P>Calreticulin, upon translocation to the cell surface, plays a critical role in the recognition of tumour cells and in experimentally induced cellular anti-tumour immunity. However, less is known about anti-calreticulin antibodies and their role in malignancies. Using enzyme-linked immunosorbent assay (ELISA), we found immunoglobulin (Ig)A and/or IgG anti-calreticulin antibodies in sera of approximately 63% of patients with hepatocellular carcinoma (HCC), 57% of patients with colorectal adenocarcinoma (CRA) and 47% of patients with pancreatic adenocarcinoma (PACA), while healthy controls, patients with viral hepatitis C and with chronic pancreatitis reached only 2%, 20% and 31% seropositivity, respectively. We found significantly elevated mean levels of IgA anti-calreticulin antibodies (P < 0 center dot 001) in patients with HCC (78 center dot 7 +/- 52 center dot 3 AU, mean +/- standard deviation), PACA (66 center dot 5 +/- 30 center dot 9 AU) and CRA (61 center dot 8 +/- 25 center dot 8 AU) wh P>Calreticulin, upon translocation to the cell surface, plays a critical role in the recognition of tumour cells and in experimentally induced cellular anti-tumour immunity. However, less is known about anti-calreticulin antibodies and their role in malignancies. Using enzyme-linked immunosorbent assay (ELISA), we found immunoglobulin (Ig)A and/or IgG anti-calreticulin antibodies in sera of approximately 63% of patients with hepatocellular carcinoma (HCC), 57% of patients with colorectal adenocarcinoma (CRA) and 47% of patients with pancreatic adenocarcinoma (PACA), while healthy controls, patients with viral hepatitis C and with chronic pancreatitis reached only 2%, 20% and 31% seropositivity, respectively. We found significantly elevated mean levels of IgA anti-calreticulin antibodies (P < 0 center dot 001) in patients with HCC (78 center dot 7 +/- 52 center dot 3 AU, mean +/- standard deviation), PACA (66 center dot 5 +/- 30 center dot 9 AU) and CRA (61 center dot 8 +/- 25 center dot 8 AU) wh (en)
Title	Calreticulin is a B cell molecular target in some gastrointestinal malignancies Calreticulin is a B cell molecular target in some gastrointestinal malignancies (en)
skos:prefLabel	Calreticulin is a B cell molecular target in some gastrointestinal malignancies Calreticulin is a B cell molecular target in some gastrointestinal malignancies (en)
skos:notation	RIV/00023001:_____/10:00002374!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06155), P(GA310/07/0414), P(GD310/08/H077), P(IAA500200709), P(IAA500200801), P(NS9705), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Drastich, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	249529
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002374
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antigenic epitopes; autoantibodies; calreticulin; hepatocellular carcinoma; pancreatic adenocarcinoma (en)
http://linked.open.../riv/klicoveSlovo	autoantibodies calreticulin hepatocellular carcinoma pancreatic adenocarcinoma antigenic epitopes
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DF101244E47B]
http://linked.open...i/riv/nazevZdroje	Clinical and experimental immunology
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Occurrence, analysis of fine specificity and biological role of serum autoantibodies against calreticulin and tissue transglutaminase in patients with oncological diseases and selected risk groups The association of chronic liver disease with coeliac disease Identification of new markers for molecular diagnosis of inflammatory and tumor diseases. The role of innate and adaptive immunity in development of gluten-sensitive entheropathy Regulation of immunological mechanisms in health and disease:Development of new diagnostic and therapeutic approaches Food allergy to wheat proteins
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	160
http://linked.open...iv/tvurceVysledku	Drastich, Pavel Hoffmanová, I. Mothes, T. Janatková, I. Tlaskalová-Hogenová, H. Palová-Jelínková, L. Sánchez, D. Benes, Z. Pekáriková, A. Simsová, M. Tucková, L.
http://linked.open...ain/vavai/riv/wos	000276499400009
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0009-9104
number of pages	8 (xsd:int)

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